Plasticity mechanisms of genetically distinct Purkinje cells.

Autor: Voerman S; Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands., Broersen R; Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands., Swagemakers SMA; Department of Pathology and Clinical Bioinformatics, Erasmus MC, Rotterdam, The Netherlands., De Zeeuw CI; Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.; Netherlands Institute for Neuroscience, Amsterdam, The Netherlands., van der Spek PJ; Department of Pathology and Clinical Bioinformatics, Erasmus MC, Rotterdam, The Netherlands.
Jazyk: angličtina
Zdroj: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2024 Jun; Vol. 46 (6), pp. e2400008. Date of Electronic Publication: 2024 May 02.
DOI: 10.1002/bies.202400008
Abstrakt: Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms.
(© 2024 The Authors. BioEssays published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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