68 Ga-FAP-2286 PET of Solid Tumors: Biodistribution, Dosimetry, and Comparison with 18 F-FDG.
| Autor: | Kline B; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California., Yadav S; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California., Seo Y; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California., Ippisch RC; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California., Castillo J; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California., Aggarwal RR; Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, California., Kelley RK; Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, California., Behr SC; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California., Flavell RR; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.; Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, California., Lawhn-Heath C; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California., Melisko M; Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, California., Rugo HS; Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, California., Wang V; Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, California., Yom SS; Department of Radiation Oncology, University of California San Francisco, San Francisco, California., Ha P; Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, California; and., Jiang F; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California., Hope TA; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California; thomas.hope@ucsf.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2024 Jun 03; Vol. 65 (6), pp. 938-943. Date of Electronic Publication: 2024 Jun 03. |
| DOI: | 10.2967/jnumed.123.267281 |
| Abstrakt: | Fibroblast activation protein (FAP), expressed in the tumor microenvironment of a variety of cancers, has become a target of novel PET tracers. The purpose of this report is to evaluate the imaging characteristics of 68 Ga-FAP-2286, present the first-to our knowledge-dosimetry analysis to date, and compare the agent with 18 F-FDG and FAPI compounds. Methods: Patients were administered 219 ± 43 MBq of 68 Ga-FAP-2286 and scanned after 60 min. Uptake was measured in up to 5 lesions per patient and within the kidneys, spleen, liver, and mediastinum (blood pool). Absorbed doses were evaluated using MIM Encore and OLINDA/EXM version 1.1 using the International Commission on Radiological Protection publication 103 tissue weighting factor. Results: Forty-six patients were imaged with 68 Ga-FAP-2286 PET. The highest average uptake was seen in sarcoma, cholangiocarcinoma, and colon cancer. The lowest uptake was found in lung cancer and testicular cancer. The average SUV (© 2024 by the Society of Nuclear Medicine and Molecular Imaging.) |
| Databáze: | MEDLINE |
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