Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients.

Autor: An KY; Faculty of Kinesiology, Sport, and Recreation, College of Health Sciences, University of Alberta, Edmonton T6G 2H9, Canada., Arthuso FZ; Faculty of Kinesiology, Sport, and Recreation, College of Health Sciences, University of Alberta, Edmonton T6G 2H9, Canada., Filion M; Faculty of Kinesiology, Sport, and Recreation, College of Health Sciences, University of Alberta, Edmonton T6G 2H9, Canada., Allen SJ; Faculty of Kinesiology, Sport, and Recreation, College of Health Sciences, University of Alberta, Edmonton T6G 2H9, Canada., Ntoukas SM; Faculty of Kinesiology, Sport, and Recreation, College of Health Sciences, University of Alberta, Edmonton T6G 2H9, Canada., Bell GJ; Faculty of Kinesiology, Sport, and Recreation, College of Health Sciences, University of Alberta, Edmonton T6G 2H9, Canada., McNeil J; Department of Kinesiology, School of Health and Human Sciences, University of North Carolina at Greensboro, Greensboro, NC 27412, USA., Wang Q; Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary T2S 3C3, Canada., McNeely ML; Faculty of Rehabilitation Medicine, University of Alberta, Edmonton T6G 2H9, Canada., Vallance JK; Faculty of Health Disciplines, Athabasca University, Athabasca T9S 3A3, Canada., Yang L; Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary T2S 3C3, Canada; Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary T2N 4N1, Canada., Culos-Reed SN; Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary T2N 4N1, Canada; Faculty of Kinesiology, University of Calgary, Calgary T2N 1N4, Canada., Dickau L; Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary T2S 3C3, Canada., Mackey JR; Faculty of Medicine and Dentistry, University of Alberta, Edmonton T6G 2H9, Canada., Friedenreich CM; Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary T2S 3C3, Canada; Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary T2N 4N1, Canada., Courneya KS; Faculty of Kinesiology, Sport, and Recreation, College of Health Sciences, University of Alberta, Edmonton T6G 2H9, Canada. Electronic address: kerry.courneya@ualberta.ca.
Jazyk: angličtina
Zdroj: Journal of sport and health science [J Sport Health Sci] 2024 Nov; Vol. 13 (6), pp. 851-862. Date of Electronic Publication: 2024 May 01.
DOI: 10.1016/j.jshs.2024.04.012
Abstrakt: Background: Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life, treatment outcomes, and survival. Preventing and managing breast cancer-related symptoms soon after diagnosis is essential. The purpose of this study was to investigate the associations between health-related fitness (HRF) and patient-reported symptoms in newly diagnosed breast cancer patients.
Methods: This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of diagnosis. HRF measures included peak cardiopulmonary fitness (peak volume of oxygen consumption (VO 2peak )), maximal muscular strength and endurance, flexibility, and body composition. Symptom measures included depression, sleep quality, and fatigue. Adjusted multivariable logistic regression was performed for analyses.
Results: Of 1458 participants, 51.5% reported poor sleep quality, 26.5% reported significant fatigue, and 10.4% reported moderate depression. In multivariable-adjusted models, lower relative VO 2peak was independently associated with a greater likelihood of all symptom measures, including moderate depression (p < 0.001), poor sleep quality (p = 0.009), significant fatigue (p = 0.008), any symptom (p < 0.001), and multiple symptoms (p < 0.001). VO 2peak demonstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest quartile. The strength of the threshold associations varied by the symptom measure with odds ratios ranging from ∼1.5 for poor sleep quality to ∼3.0 for moderate depression and multiple symptoms. Moreover, lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner (p = 0.001), and higher body weight was independently associated with poor sleep quality in an inverted U pattern (p = 0.021).
Conclusion: Relative VO 2peak appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diagnosed breast cancer patients. Other HRF parameters may also be important for specific symptoms. Exercise interventions targeting different HRF components may help newly diagnosed breast cancer patients manage specific symptoms and improve outcomes.
(Copyright © 2024. Production and hosting by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: