Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures.

Autor:	Nair VD; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: venugopalan.nair@mountsinai.org., Pincas H; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Smith GR; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Zaslavsky E; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ge Y; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Amper MAS; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Vasoya M; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Chikina M; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Sun Y; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Raja AN; Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Mao W; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Gay NR; Department of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA., Esser KA; Department of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA., Smith KS; Departments of Pathology and Genetics, Stanford School of Medicine, Stanford, CA 94305, USA., Zhao B; Department of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA., Wiel L; Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Singh A; Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Lindholm ME; Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Amar D; Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Montgomery S; Departments of Pathology and Genetics, Stanford School of Medicine, Stanford, CA 94305, USA., Snyder MP; Department of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA., Walsh MJ; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Sealfon SC; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: stuart.sealfon@mssm.edu.
Jazyk:	angličtina
Zdroj:	Cell genomics [Cell Genom] 2024 Jun 12; Vol. 4 (6), pp. 100421. Date of Electronic Publication: 2024 May 01.
DOI:	10.1016/j.xgen.2023.100421
Abstrakt:	Regular exercise has many physical and brain health benefits, yet the molecular mechanisms mediating exercise effects across tissues remain poorly understood. Here we analyzed 400 high-quality DNA methylation, ATAC-seq, and RNA-seq datasets from eight tissues from control and endurance exercise-trained (EET) rats. Integration of baseline datasets mapped the gene location dependence of epigenetic control features and identified differing regulatory landscapes in each tissue. The transcriptional responses to 8 weeks of EET showed little overlap across tissues and predominantly comprised tissue-type enriched genes. We identified sex differences in the transcriptomic and epigenomic changes induced by EET. However, the sex-biased gene responses were linked to shared signaling pathways. We found that many G protein-coupled receptor-encoding genes are regulated by EET, suggesting a role for these receptors in mediating the molecular adaptations to training across tissues. Our findings provide new insights into the mechanisms underlying EET-induced health benefits across organs. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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