Estimating Gender Differences in the Association between Cognitive Resilience and Mild Cognitive Impairment Incidence.

Autor:	Leung Y; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.; Neuroscience Research Australia, Sydney, New South Wales, Australia.; UNSW Ageing Futures Institute, University of New South Wales, Sydney, New South Wales, Australia., Eramudugolla R; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia., Cherbuin N; Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia., Peters R; UNSW Ageing Futures Institute, University of New South Wales, Sydney, New South Wales, Australia.; George Institute for Global Health, Sydney, New South Wales, Australia., Mortby ME; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.; Neuroscience Research Australia, Sydney, New South Wales, Australia.; UNSW Ageing Futures Institute, University of New South Wales, Sydney, New South Wales, Australia., Kiely KM; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.; Neuroscience Research Australia, Sydney, New South Wales, Australia.; UNSW Ageing Futures Institute, University of New South Wales, Sydney, New South Wales, Australia.; School of Health and Society, and School of Mathematics and Applied Statistics, University of Wollongong, Sydney, New South Wales, Australia., Anstey KJ; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.; Neuroscience Research Australia, Sydney, New South Wales, Australia.; UNSW Ageing Futures Institute, University of New South Wales, Sydney, New South Wales, Australia.
Jazyk:	angličtina
Zdroj:	Gerontology [Gerontology] 2024; Vol. 70 (7), pp. 776-784. Date of Electronic Publication: 2024 May 03.
DOI:	10.1159/000538615
Abstrakt:	Introduction: Recent evidence suggests that the influence of verbal intelligence and education on the onset of subjective cognitive decline may be modulated by gender, where education contributes less to cognitive resilience (CR) in women than in men. This study aimed to examine gender differences in the association between CR and mild cognitive impairment (MCI) incidence in an Australian population-based cohort. Methods: We included 1,806 participants who had completed at least the first two waves and up to four waves of assessments in the Personality and Total Health (PATH) Through Life study (baseline: 49% female, male = 62.5, SD = 1.5, age range = 60-66 years). CR proxies included measures of educational attainment, occupation skill, verbal intelligence, and leisure activity. Discrete-time survival analyses were conducted to examine gender differences in the association between CR proxies and MCI risk, adjusting for age and apolipoprotein E4 status. Results: Gender differences were only found in the association between occupation and MCI risk, where lower occupation skill was more strongly associated with higher risk in men than in women (odds ratio [OR] = 1.30, 95% confidence interval [CI] [1.07, 1.57]). In both genders, after adjusting for education and occupation, one SD increase in leisure activity was associated with lower MCI risk by 32% (OR = 0.76, 95% CI [0.65, 0.89]). Higher scores in verbal intelligence assessment were associated with reduced risk of MCI by 28% (OR = 0.78, 95% CI [0.69, 0.89]). Conclusion: Occupational experience may contribute to CR differently between genders. Life course cognitive engagement and verbal intelligence may be more protective against MCI than education and occupation for both men and women. (© 2024 S. Karger AG, Basel.)
Databáze:	MEDLINE
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