Early Hypophosphatemia as a Prognostic Marker in Acute Pancreatitis.

Autor:	Stewart CF; From the Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA., Adeniran EA; From the Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA., Yadav D; Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA., Gorelick FS; Department of Medicine (Digestive Diseases), Yale University School of Medicine, New Haven, CT., Liddle RA; Department of Medicine, Duke University School of Medicine, Durham, NC., Wu B; Department of Gastroenterology, Kaiser-Permanente Medical Center, Los Angeles, CA., Pandol SJ; Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA., Jeon CY; From the Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Jazyk:	angličtina
Zdroj:	Pancreas [Pancreas] 2024 Aug 01; Vol. 53 (7), pp. e611-e616. Date of Electronic Publication: 2024 May 01.
DOI:	10.1097/MPA.0000000000002344
Abstrakt:	Objectives: Acute pancreatitis (AP) is a complex disease representing a significant portion of gastrointestinal-related hospitalizations in the U.S. Understanding risk factors of AP might provide attractive therapeutic targets. We evaluated hypophosphatemia a prognostic marker in AP. Methods: We performed a retrospective review of electronic health records of patients with AP from 01/ 01/2012-12/31/2021 at Cedars-Sinai Medical Center with serum phosphate measured within 48 hours of admission. Multivariable logistic regression modeling was used to evaluate associations with ICU admission and AP severity. Multivariable log-linear modeling was employed to examine associations with length of stay (LOS). Results: Of 1526 patients admitted for AP, 33% (499) had a serum phosphate level measured within 48 hours. Patients with hypophosphatemia were more likely to have ICU admission (adjusted odds ratio (AOR) = 4.57; 95% confidence interval (CI): 2.75-7.62; P < 0.001), have a longer hospital stay (log-LOS = 0.34; SE; 0.09; 95% CI: 0.17-0.52; P < 0.001), and have moderate or severe AP (AOR = 1.80; 95% CI: 1.16-2.80; P < 0.001) compared with those without hypophosphatemia. Conclusion: Serum phosphate is infrequently measured in patients with AP and shows promise as an early prognostic marker for outcomes of AP. Competing Interests: The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Defense. The authors declare no conflict of interest. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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