Quantifying Putative Retinal Gliosis in Preclinical Alzheimer's Disease.

Autor:	Ravichandran S; School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, United States., Snyder PJ; Department of Neurology, Alpert Medical School of Brown University, Providence, Rhode Island, United States.; Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island, United States., Alber J; Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island, United States.; George and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, Rhode Island, United States.; Butler Hospital Memory and Aging Program, Providence, Rhode Island, United States., Kenny MR; School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, United States., Rothstein A; School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, United States., Brown K; School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, United States., Murchison CF; Alzheimer's Disease Research Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, United States.; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, United States., Clay OJ; Alzheimer's Disease Research Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, United States.; Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, United States., Roberson ED; Alzheimer's Disease Research Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, United States., Arthur E; School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Jazyk:	angličtina
Zdroj:	Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2024 May 01; Vol. 65 (5), pp. 5.
DOI:	10.1167/iovs.65.5.5
Abstrakt:	Purpose: Neuroinflammation plays a significant role in the pathology of Alzheimer's disease (AD). Mouse models of AD and postmortem biopsy of patients with AD reveal retinal glial activation comparable to central nervous system immunoreactivity. We hypothesized that the surface area of putative retinal gliosis observed in vivo using en face optical coherence tomography (OCT) imaging will be larger in patients with preclinical AD versus controls. Methods: The Spectralis II instrument was used to acquire macular centered 20 × 20 and 30 × 25-degrees spectral domain OCT images of 76 participants (132 eyes). A cohort of 22 patients with preclinical AD (40 eyes, mean age = 69 years, range = 60-80 years) and 20 control participants (32 eyes, mean age = 66 years, range = 58-82 years, P = 0.11) were included for the assessment of difference in surface area of putative retinal gliosis and retinal nerve fiber layer (RNFL) thickness. The surface area of putative retinal gliosis and RNFL thickness for the nine sectors of the Early Treatment Diabetic Retinopathy Study (ETDRS) map were compared between groups using generalized linear mixed models. Results: The surface area of putative retinal gliosis was significantly greater in the preclinical AD group (0.97 ± 0.55 mm2) compared to controls (0.68 ± 0.40 mm2); F(1,70) = 4.41, P = 0.039; Cohen's d = 0.61. There was no significant difference between groups for RNFL thickness in the 9 ETDRS sectors, P > 0.05. Conclusions: Our analysis shows greater putative retinal gliosis in preclinical AD compared to controls. This demonstrates putative retinal gliosis as a potential biomarker for AD-related neuroinflammation.
Databáze:	MEDLINE
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