Total Synthesis of Lissodendoric Acid A.

Autor: Ippoliti FM; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Department of Chemistry, Hamline University, St. Paul, Minnesota, 55104, USA., Wonilowicz LG; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA., Adamson NJ; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA 94080, USA., Darzi ER; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.; ElectraTect, Inc., Phoenix, AZ 85004, USA., Donaldson JS; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Pfizer Oncology Medicinal Chemistry, San Diego, CA 92121, USA., Nasrallah DJ; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Department of Chemistry, Roanoke College, Salem, Virginia, 24153, USA., Mehta MM; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Small Molecule Therapeutic Discovery, Amgen Research, Amgen Inc., Thousand Oaks, CA 91320, USA., Kelleghan AV; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Gilead Sciences Medicinal Chemistry, Foster City, CA 94404, USA., Houk KN; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA., Garg NK; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Aug 05; Vol. 63 (32), pp. e202406676. Date of Electronic Publication: 2024 Jul 03.
DOI: 10.1002/anie.202406676
Abstrakt: We describe a full account of our synthetic strategy leading to the first total synthesis of the manzamine alkaloid lissodendoric acid A . These efforts demonstrate that strained cyclic allenes are valuable synthetic building blocks and can be employed efficiently in total synthesis.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: