Insecticidal effect of new synthesized chalcone derivatives on Caribbean fruit fly, Anastrepha suspensa .
| Autor: | Yücetepe S; 52982 Institute of Health Sciences, Marmara University , 34865, Istanbul, Türkiye., Koçyiğit-Kaymakçıoğlu B; Department of Pharmaceutical Chemistry, 20420479 Faculty of Pharmacy, Biruni University , 34015, Istanbul, Türkiye., Yang X; 2017123 United States Department of Agriculture-Agricultural Research Service (USDA-ARS) , Subtropical Horticulture Research Station (SHRS), 13601 Old Cutler Rd., Miami, FL 33158, USA., Tabanca N; 2017123 United States Department of Agriculture-Agricultural Research Service (USDA-ARS) , Subtropical Horticulture Research Station (SHRS), 13601 Old Cutler Rd., Miami, FL 33158, USA., Tok F; Department of Pharmaceutical Chemistry, 52982 Faculty of Pharmacy, Marmara University , 34854, Istanbul, Türkiye. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Zeitschrift fur Naturforschung. C, Journal of biosciences [Z Naturforsch C J Biosci] 2024 May 03. Date of Electronic Publication: 2024 May 03. |
| DOI: | 10.1515/znc-2024-0005 |
| Abstrakt: | In this present study, new chalcone derivatives were synthesized from 4-aminoacetophenone, which were confirmed by spectroscopic methods. The toxic risks of chalcones to humans and the environment were investigated by a web-based platform called ADMETlab. With this program, the possible toxic effects of the compounds on liver, respiratory system, and eyes were evaluated. For the topical insecticidal activity, adult female Caribbean fruit fly, Anastrepha suspensa , was targeted. Results of the toxicity tests showed that chalcone derivatives are effective against female A. suspensa . Among the synthesized chalcones, 1-(4-cinnamoylphenyl)-3-( p -tolyl)urea ( 2 ) exhibited the greatest insecticidal activity, resulting in 73 % mortality at 100 µg/fly after 24 h, whereas other derivatives showed less than 30 % mortality. Our results demonstrate that insecticidal activity may be modulated by the presence of a certain phenyl ring in the structure of derivative 2 and, therefore, has potential for design of efficient chemicals for tephritid fruit fly management. (© 2024 the author(s), published by De Gruyter, Berlin/Boston.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|