A 12-week multicomponent exercise program enhances frailty by increasing robustness, improves physical performance, and preserves muscle mass in older adults with HIV: MOVIhNG study.

Autor:	Brañas F; Geriatrics Department, Hospital Universitario Infanta Leonor, Madrid, Spain.; FIIB H.U Infanta Leonor y H.U. Sureste, Madrid, Spain.; Medicine Department, Universidad Complutense, Madrid, Spain., Díaz-Álvarez J; Infectious Diseases Department, Hospital Universitario Ramón y Cajal. IRYCIS, Madrid, Spain., Fernández-Luna J; Primary Care Service, Centro de Salud Fuentelarreina, Madrid, Spain., Vásquez-Brolen BD; Geriatrics Department, Hospital Universitario Infanta Leonor, Madrid, Spain., García-Molina R; Geriatrics Department, Hospital Nuestra Señora del Perpetuo Socorro, Albacete, Spain.; CIBER de Envejecimiento y Fragilidad (CIBERFES), ISCIII, Madrid, Spain., Moreno E; Infectious Diseases Department, Hospital Universitario Ramón y Cajal. IRYCIS, Madrid, Spain.; CIBER de Enfermedades Infecciosas (CIBERINFEC). ISCIIII, Madrid, Spain., Ryan P; FIIB H.U Infanta Leonor y H.U. Sureste, Madrid, Spain.; Medicine Department, Universidad Complutense, Madrid, Spain.; CIBER de Enfermedades Infecciosas (CIBERINFEC). ISCIIII, Madrid, Spain.; HIV Clinic, Hospital Universitario Infanta Leonor, Madrid, Spain., Martínez-Sanz J; Infectious Diseases Department, Hospital Universitario Ramón y Cajal. IRYCIS, Madrid, Spain.; CIBER de Enfermedades Infecciosas (CIBERINFEC). ISCIIII, Madrid, Spain., Luna L; Infectious Diseases Department, Hospital Universitario Ramón y Cajal. IRYCIS, Madrid, Spain.; CIBER de Enfermedades Infecciosas (CIBERINFEC). ISCIIII, Madrid, Spain., Martínez M; Geriatrics Department, Hospital Universitario Infanta Leonor, Madrid, Spain.; Medicine Department, Universidad Complutense, Madrid, Spain., Dronda F; Infectious Diseases Department, Hospital Universitario Ramón y Cajal. IRYCIS, Madrid, Spain., Sánchez-Conde M; Infectious Diseases Department, Hospital Universitario Ramón y Cajal. IRYCIS, Madrid, Spain.; CIBER de Enfermedades Infecciosas (CIBERINFEC). ISCIIII, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2024 Apr 17; Vol. 12, pp. 1373910. Date of Electronic Publication: 2024 Apr 17 (Print Publication: 2024).
DOI:	10.3389/fpubh.2024.1373910
Abstrakt:	Background: Our aim was to analyze the effects of a multicomponent exercise program (MEP) on frailty and physical performance in older adults with HIV (OAWH) since exercise can reverse frailty in the older population overall, but there is no data for OAWH. Methods: A prospective longitudinal study with intervention and control group was designed. Sedentary adults 50 or over with and without HIV were included. The intervention was a 12-week home-based MEP. Dependent variables were frailty (frailty phenotype), physical performance (Senior Fitness Test), muscle mass (ASMI) by bioimpedance. Pre- and postintervention measurements were analyzed using McNemar's test for categorical variables and the Wilcoxon signed-rank test for quantitative variables. Results: 40 OAWH and 20 OA without HIV. The median age was 56.5 years. 23.3% were women. The prevalence of frailty was 6.6% with no frail HIV-negative participants. Three of the four frail HIV-participants transitioned two (50%) from frail to prefrail and one (25%) to robust after the MEP. In participants with an adherence ≥50%, physical performance was significantly improved [basal vs. 12 week]: upper extremity strength [13 (13-15) vs. 16 (15-19), p = 0.0001], lower extremity strength [13 (11-16) vs. 15 (13-16), p = 0.004], aerobic endurance [62 (55-71) vs. 66 (58-80), p = 0.005]. Participants with low adherence experienced a significant worsening in ASMI [8.35 (7.44-9.26) vs. 7.09 (6.08-8.62), p = 0.03]. Conclusion: A 12-week MEP enhances frailty by increasing robustness in OAWH, and improves physical performance, and preserves muscle mass in older adults with good adherence to the MEP independently of HIV status. Competing Interests: FB reports research grant from MSD, non-financial support from Nestlé, and personal fees from ViiV Healthcare, Gilead, AMGEN, UCB, Grünenthal, Abbott, Vegenat, and Nestlé. MS-C reports research grant from Gilead, educational grants from MSD, Gilead, and ViiV Healthcare, and personal fees and non-financial support from Gilead. PR reports grants and personal fees from Gilead and personal fees from ViiV Healthcare and Abbvie. BV-B reports grants from Nutricia, and personal fees from Abbott nutrition, and Fresenius Kabi. EM reports conference attendance support from Gilead and ViiV Healthcare. JM-S reports personal fees from ViiV Healthcare, Janssen, Gilead, and MSD, non-financial support from ViiV Healthcare, Jannsen, and Gilead, and research grants from Gilead. FD has received research grants or honoraria for lectures or for participation in advisory boards from Gilead, ViiV-Healthcare, and unrestricted grants from ViiV Healthcare and Gilead. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Brañas, Díaz-Álvarez, Fernández-Luna, Vásquez-Brolen, García-Molina, Moreno, Ryan, Martínez-Sanz, Luna, Martínez, Dronda and Sánchez-Conde.)
Databáze:	MEDLINE
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