Bimaxillary fixed implant-supported zirconium oxide prosthesis therapy of an adolescent patient with non-syndromic oligodontia and two WNT10 variants: a case report.

Autor:	Grün P; Center for Oral and Maxillofacial Surgery, Department of Dentistry., Pfaffeneder-Mantai F; Center for Oral and Maxillofacial Surgery, Department of Dentistry.; Division for Chemistry and Physics of Materials, Department of Medicine, Faculty of Medicine and Dentistry, Danube Private University, Krems, Austria., Leunig N; Center for Oral and Maxillofacial Surgery, Department of Dentistry., Bytyqi D; Center for Oral and Maxillofacial Surgery, Department of Dentistry., Maier C; Practice for Orthodontics, Hohenauerstraße, Mühldorf am Inn, Germany., Gencik M; Practice for Human Genetics, Brünnlbadgasse, Vienna, Austria., Bandura P; Center for Oral and Maxillofacial Surgery, Department of Dentistry., Turhani D; Center for Oral and Maxillofacial Surgery, Department of Dentistry.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2024 Mar 19; Vol. 86 (5), pp. 3072-3081. Date of Electronic Publication: 2024 Mar 19 (Print Publication: 2024).
DOI:	10.1097/MS9.0000000000001936
Abstrakt:	Introduction and Importance: Oligodontia is a rare genetic condition characterized by more than six congenitally missing teeth, either as an isolated non-syndromic condition or in association with other genetic syndromes. The impact of WNT10A variants on dental development increases with the presence of the c.321C>A variant and the number of missing teeth. Case Presentation: A 21-year-old man with non-syndromic oligodontia was diagnosed at 15 years of age with misaligned teeth, speech problems, and the absence of 24 permanent teeth. Interdisciplinary collaboration between specialists was initiated to enable comprehensive treatment. DNA analysis confirmed that the patient was a carrier of the known pathogenic WNT10A variant c321C>A and WNT10A variant c.113G>T of unknown clinical significance. Clinical Discussion: Dental implants are a common treatment; however, bone development challenges in adolescent patients with non-syndromic oligodontia necessitate careful planning to ensure implant success. Many WNT variants play crucial roles in tooth development and are directly involved in non-syndromic oligodontia, especially the WNT10 variant c.321C>A. Conclusion: A full-arch implant-supported monolithic zirconia screw-retained fixed prosthesis is a viable treatment option for young adults with non-syndromic oligodontia. Further studies are needed to clarify the possible amplifying effect of the WNT10A variants c321C>A and c.113G>T on the pathogenic phenotype of non-syndromic oligodontia. Competing Interests: The authors declare that there are no conflicts of interest.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu