Prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-neutrophil (PN) index in locally advanced rectal cancer patients: a retrospective cohort study.
| Autor: | Morais M; Departments of Surgery., Fonseca T; Departments of Surgery., Machado-Neves R; Pathologic Anatomy, Unidade Local de Saúde de Matosinhos, da Hora., Honavar M; Pathologic Anatomy, Unidade Local de Saúde de Matosinhos, da Hora., Coelho AR; Pathologic Anatomy, Centro Hospitalar Universitário de São João, Porto, Portugal., Lopes J; Pathologic Anatomy, Centro Hospitalar Universitário de São João, Porto, Portugal., Guerreiro E; Departments of Surgery., Carneiro S; Departments of Surgery. |
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| Jazyk: | angličtina |
| Zdroj: | Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2024 Mar 18; Vol. 86 (5), pp. 2474-2480. Date of Electronic Publication: 2024 Mar 18 (Print Publication: 2024). |
| DOI: | 10.1097/MS9.0000000000001297 |
| Abstrakt: | Introduction: In locally advanced rectal cancers (LARC), tumour node metastasis (TNM) staging is far from optimal. The authors aimed to investigate the value of previously described circulating biomarkers as predictors of prognosis. Methods: Retrospective analysis of 245 LARC patients diagnosed between January 2010 and December 2022, who underwent neoadjuvant chemoradiotherapy and surgery at two centres. A Cox regression and Kaplan-Meier analysis were performed. Results: Post-treatment platelet-to-lymphocyte ratio (PLR) predicted pathological complete response. The neutrophil-to-lymphocyte ratio (NLR) in two timepoints of the treatment significantly predicted overall survival, whereas the platelet-neutrophil (PN) index significantly predicted disease-free survival. In pathological stage II, the PN index predicted patients with a higher risk of disease-free survival. Conclusion: Blood parameters might allow the definition of subgroups of risk beyond TNM for the application of different therapeutic strategies. Competing Interests: The authors declares that they have no conflicts of interest.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.) |
| Databáze: | MEDLINE |
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