Geographic variation of mutagenic exposures in kidney cancer genomes.

Autor: Senkin S; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Moody S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Díaz-Gay M; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Abedi-Ardekani B; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Cattiaux T; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Ferreiro-Iglesias A; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Wang J; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Fitzgerald S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Kazachkova M; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA., Vangara R; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Le AP; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Bergstrom EN; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Khandekar A; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Otlu B; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Department of Health Informatics, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey., Cheema S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Latimer C; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Thomas E; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Atkins JR; Cancer Epidemiology Unit, The Nuffield Department of Population Health, University of Oxford, Oxford, UK., Smith-Byrne K; Cancer Epidemiology Unit, The Nuffield Department of Population Health, University of Oxford, Oxford, UK., Cortez Cardoso Penha R; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Carreira C; Evidence Synthesis and Classification Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Chopard P; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Gaborieau V; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Keski-Rahkonen P; Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Jones D; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Teague JW; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Ferlicot S; Service d'Anatomie Pathologique, Assistance Publique-Hôpitaux de Paris, Univeristé Paris-Saclay, Le Kremlin-Bicêtre, France., Asgari M; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.; Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran., Sangkhathat S; Translational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand., Attawettayanon W; Division of Urology, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand., Świątkowska B; Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland., Jarmalaite S; Laboratory of Genetic Diagnostic, National Cancer Institute, Vilnius, Lithuania.; Department of Botany and Genetics, Institute of Biosciences, Vilnius University, Vilnius, Lithuania., Sabaliauskaite R; Laboratory of Genetic Diagnostic, National Cancer Institute, Vilnius, Lithuania., Shibata T; Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.; Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Japan., Fukagawa A; Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Japan.; Department of Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan., Mates D; Occupational Health and Toxicology Department, National Center for Environmental Risk Monitoring, National Institute of Public Health, Bucharest, Romania., Jinga V; Urology Department, Carol Davila University of Medicine and Pharmacy, Prof. Dr. Th. Burghele Clinical Hospital, Bucharest, Romania., Rascu S; Urology Department, Carol Davila University of Medicine and Pharmacy, Prof. Dr. Th. Burghele Clinical Hospital, Bucharest, Romania., Mijuskovic M; Clinic of Nephrology, Faculty of Medicine, Military Medical Academy, Belgrade, Serbia., Savic S; Department of Urology, University Hospital Dr D. Misovic Clinical Center, Belgrade, Serbia., Milosavljevic S; International Organization for Cancer Prevention and Research, Belgrade, Serbia., Bartlett JMS; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Albert M; Centre for Biodiversity Genomics, University of Guelph, Guelph, Ontario, Canada.; Ontario Tumour Bank, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Phouthavongsy L; Ontario Tumour Bank, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Ashton-Prolla P; Experimental Research Center, Genomic Medicine Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Post-Graduate Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Botton MR; Transplant Immunology and Personalized Medicine Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Silva Neto B; Service of Urology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Post-Graduate Program in Medicine: Surgical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Bezerra SM; Department of Anatomic Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil., Curado MP; Department of Epidemiology, A. C. Camargo Cancer Center, São Paulo, Brazil., Zequi SC; Department of Urology, A. C. Camargo Cancer Center, São Paulo, Brazil.; National Institute for Science and Technology in Oncogenomics and Therapeutic Innovation, A.C. Camargo Cancer Center, São Paulo, Brazil.; Latin American Renal Cancer Group (LARCG), São Paulo, Brazil.; Department of Surgery, Division of Urology, Sao Paulo Federal University (UNIFESP), São Paulo, Brazil., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.; Life and Health Sciences Research Institute (ICVS), School of Medicine, Minho University, Braga, Portugal., Faria EF; Faculdade Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil.; Department of Urology, Barretos Cancer Hospital, Barretos, Brazil., de Menezes NS; Department of Pathology, Barretos Cancer Hospital, Barretos, Brazil., Ferrari RS; Department of Urology, Barretos Cancer Hospital, Barretos, Brazil., Banks RE; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Vasudev NS; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Zaridze D; Department of Clinical Epidemiology, N. N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia., Mukeriya A; Department of Clinical Epidemiology, N. N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia., Shangina O; Department of Clinical Epidemiology, N. N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia., Matveev V; Department of Urology, N. N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia., Foretova L; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Navratilova M; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Holcatova I; Institute of Public Health and Preventive Medicine, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.; Department of Oncology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic., Hornakova A; Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic., Janout V; Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic., Purdue MP; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Rothman N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Ueland PM; Bevital AS, Bergen, Norway., Johansson M; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., McKay J; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Scelo G; Observational and Pragmatic Research Institute Pte Ltd, Singapore, Singapore., Chanudet E; Department of Pathology, Radboud University Medical Centre, Nijmegen, Netherlands., Humphreys L; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., de Carvalho AC; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Perdomo S; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Alexandrov LB; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Stratton MR; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Brennan P; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. brennanp@iarc.who.int.
Jazyk: angličtina
Zdroj: Nature [Nature] 2024 May; Vol. 629 (8013), pp. 910-918. Date of Electronic Publication: 2024 May 01.
DOI: 10.1038/s41586-024-07368-2
Abstrakt: International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to cancer burden 1 . In clear cell renal cell carcinoma, obesity, hypertension and tobacco smoking are risk factors, but they do not explain the geographical variation in its incidence 2 . Underlying causes can be inferred by sequencing the genomes of cancers from populations with different incidence rates and detecting differences in patterns of somatic mutations. Here we sequenced 962 clear cell renal cell carcinomas from 11 countries with varying incidence. The somatic mutation profiles differed between countries. In Romania, Serbia and Thailand, mutational signatures characteristic of aristolochic acid compounds were present in most cases, but these were rare elsewhere. In Japan, a mutational signature of unknown cause was found in more than 70% of cases but in less than 2% elsewhere. A further mutational signature of unknown cause was ubiquitous but exhibited higher mutation loads in countries with higher incidence rates of kidney cancer. Known signatures of tobacco smoking correlated with tobacco consumption, but no signature was associated with obesity or hypertension, suggesting that non-mutagenic mechanisms of action underlie these risk factors. The results of this study indicate the existence of multiple, geographically variable, mutagenic exposures that potentially affect tens of millions of people and illustrate the opportunities for new insights into cancer causation through large-scale global cancer genomics.
(© 2024. The Author(s).)
Databáze: MEDLINE
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