Injectable hydrogel with doxorubicin-loaded ZIF-8 nanoparticles for tumor postoperative treatments and wound repair.

Autor: Zhang Q; Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.; Tianjin Lung Cancer Center, Tianjin, China.; Tianjin's Clinical Research Center for Cancer, Tianjin, China., Zhang Y; Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.; Tianjin Lung Cancer Center, Tianjin, China.; Tianjin's Clinical Research Center for Cancer, Tianjin, China., Chen H; Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.; Tianjin Lung Cancer Center, Tianjin, China.; Tianjin's Clinical Research Center for Cancer, Tianjin, China., Sun LN; Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.; Tianjin Lung Cancer Center, Tianjin, China.; Tianjin's Clinical Research Center for Cancer, Tianjin, China.; Department of Pathology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China., Zhang B; Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.; Tianjin Lung Cancer Center, Tianjin, China.; Tianjin's Clinical Research Center for Cancer, Tianjin, China., Yue DS; Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.; Tianjin Lung Cancer Center, Tianjin, China.; Tianjin's Clinical Research Center for Cancer, Tianjin, China., Wang CL; Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.; Tianjin Lung Cancer Center, Tianjin, China.; Tianjin's Clinical Research Center for Cancer, Tianjin, China., Zhang ZF; Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China. zhangzhenfa@tmu.edu.cn.; Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. zhangzhenfa@tmu.edu.cn.; Tianjin Lung Cancer Center, Tianjin, China. zhangzhenfa@tmu.edu.cn.; Tianjin's Clinical Research Center for Cancer, Tianjin, China. zhangzhenfa@tmu.edu.cn.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 May 01; Vol. 14 (1), pp. 9983. Date of Electronic Publication: 2024 May 01.
DOI: 10.1038/s41598-024-57664-0
Abstrakt: The need for tumor postoperative treatments aimed at recurrence prevention and tissue regeneration have raised wide considerations in the context of the design and functionalization of implants. Herein, an injectable hydrogel system encapsulated with anti-tumor, anti-oxidant dual functional nanoparticles has been developed in order to prevent tumor relapse after surgery and promote wound repair. The utilization of biocompatible gelatin methacryloyl (GelMA) was geared towards localized therapeutic intervention. Zeolitic imidazolate framework-8@ceric oxide (ZIF-8@CeO2, ZC) nanoparticles (NPs) were purposefully devised for their proficiency as reactive oxygen species (ROS) scavengers. Furthermore, injectable GelMA hydrogels loaded with ZC NPs carrying doxorubicin (ZC-DOX@GEL) were tailored as multifunctional postoperative implants, ensuring the efficacious eradication of residual tumor cells and alleviation of oxidative stress. In vitro and in vivo experiments were conducted to substantiate the efficacy in cancer cell elimination and the prevention of tumor recurrence through the synergistic chemotherapy approach employed with ZC-DOX@GEL. The acceleration of tissue regeneration and in vitro ROS scavenging attributes of ZC@GEL were corroborated using rat models of wound healing. The results underscore the potential of the multifaceted hydrogels presented herein for their promising application in tumor postoperative treatments.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje