The potential of the nutraceutical berberine in the treatment of hepatocellular carcinoma and other liver diseases such as NAFLD and NASH.

Autor: Cervello M; Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy., Augello G; Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy., Cocco L; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy., Ratti S; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy., Follo MY; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy., Martelli AM; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy., Cusimano A; Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy., Montalto G; Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy; Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo School of Medicine, Palermo, Italy., McCubrey JA; Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA. Electronic address: mccubreyj@ecu.edu.
Jazyk: angličtina
Zdroj: Advances in biological regulation [Adv Biol Regul] 2024 May; Vol. 92, pp. 101032. Date of Electronic Publication: 2024 Apr 23.
DOI: 10.1016/j.jbior.2024.101032
Abstrakt: Hepatocellular carcinoma (HCC) is a common cancer which unfortunately has poor outcomes. Common anti-cancer treatments such as chemotherapy and targeted therapy have not increased patient survival significantly. A common treatment for HCC patients is transplantation, however, it has limitations and complications. Novel approaches are necessary to more effectively treat HCC patients. Berberine (BBR) is a nutraceutical derived from various fruits and trees, which has been used for centuries in traditional medicine to treat various diseases such as diabetes and inflammation. More recently, the anti-proliferation effects of BBR have been investigated in the treatment of patients with various cancers, especially colorectal cancer, and in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). In this review, we will focus on studies with BBR in liver diseases.
Competing Interests: Declaration of competing interest The authors declare that there are no competing financial interests.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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