Reduced sympathetic activity is associated with the development of pain and muscle atrophy in a female rat model of fibromyalgia.

Autor: da Silva RP; Laboratory of Basic and Behavioral Neuroendocrinology (LANBAC), Department of Physiology, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil; Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil., Costa DM; Laboratory of Basic and Behavioral Neuroendocrinology (LANBAC), Department of Physiology, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil; Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil., da Cruz-Filho J; Laboratory of Basic and Behavioral Neuroendocrinology (LANBAC), Department of Physiology, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil; Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil., Santos TO; Laboratory of Basic and Behavioral Neuroendocrinology (LANBAC), Department of Physiology, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil; Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil., Dos Anjos-Santos HC; Laboratory of Basic and Behavioral Neuroendocrinology (LANBAC), Department of Physiology, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil; Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil., Vasconcelos ABS; Laboratory of Basic and Behavioral Neuroendocrinology (LANBAC), Department of Physiology, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil; Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil., Heck LC; Department of Physiology and Biochemistry & Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., Kettelhut ÍDC; Department of Physiology and Biochemistry & Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., Navegantes LC; Department of Physiology and Biochemistry & Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., Dos Santos JR; Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil., de Souza PRM; Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil., Badauê-Passos D Jr; Laboratory of Basic and Behavioral Neuroendocrinology (LANBAC), Department of Physiology, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil., Mecawi AS; Department of Biophysics, São Paulo Medical School, Federal University of São Paulo, São Paulo, SP, Brazil., DeSantana JM; Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil; Graduate Program in Health Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil., Lustrino D; Laboratory of Basic and Behavioral Neuroendocrinology (LANBAC), Department of Physiology, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil; Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil. Electronic address: lustrino@academico.ufs.br.
Jazyk: angličtina
Zdroj: Physiology & behavior [Physiol Behav] 2024 Jul 01; Vol. 281, pp. 114575. Date of Electronic Publication: 2024 Apr 29.
DOI: 10.1016/j.physbeh.2024.114575
Abstrakt: Fibromyalgia (FM) is characterized by chronic widespread musculoskeletal pain accompanied by fatigue and muscle atrophy. Although its etiology is not known, studies have shown that FM patients exhibit altered function of the sympathetic nervous system (SNS), which regulates nociception and muscle plasticity. Nevertheless, the precise SNS-mediated mechanisms governing hyperalgesia and skeletal muscle atrophy in FM remain unclear. Thus, we employed two distinct FM-like pain models, involving intramuscular injections of acidic saline (pH 4.0) or carrageenan in prepubertal female rats, and evaluated the catecholamine content, adrenergic signaling and overall muscle proteolysis. Subsequently, we assessed the contribution of the SNS to the development of hyperalgesia and muscle atrophy in acidic saline-injected rats treated with clenbuterol (a selective β2-adrenergic receptor agonist) and in animals maintained under baseline conditions and subjected to epinephrine depletion through adrenodemedullation (ADM). Seven days after inducing an FM-like model with acidic saline or carrageenan, we observed widespread mechanical hyperalgesia along with loss of strength and/or muscle mass. These changes were associated with reduced catecholamine content, suggesting a common underlying mechanism. Notably, treatment with a β2-agonist alleviated hyperalgesia and prevented muscle atrophy in acidic saline-induced FM-like pain, while epinephrine depletion induced mechanical hyperalgesia and increased muscle proteolysis in animals under baseline conditions. Together, the results suggest that reduced sympathetic activity is involved in the development of pain and muscle atrophy in the murine model of FM analyzed.
Competing Interests: Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: