Surface dielectric resonator for in vivo EPR measurements.

Autor: Petryakov SV; Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Kmiec MM; Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Ubert CS; Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA., Kassey VB; Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Schaner PE; Department of Radiation Oncology and Applied Sciences, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Kuppusamy P; Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA; Department of Radiation Oncology and Applied Sciences, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Electronic address: Periannan.Kuppusamy@Dartmouth.edu.
Jazyk: angličtina
Zdroj: Journal of magnetic resonance (San Diego, Calif. : 1997) [J Magn Reson] 2024 May; Vol. 362, pp. 107690. Date of Electronic Publication: 2024 Apr 25.
DOI: 10.1016/j.jmr.2024.107690
Abstrakt: This research report describes a novel surface dielectric resonator (SDR) with a flexible connector for in vivo electron paramagnetic resonance (EPR) spectroscopy. Contrary to the conventional cavity or surface loop-gap resonators, the newly developed SDR is constructed from a ceramic dielectric material, and it is tuned to operate at the L-band frequency band (1.15 GHz) in continuous-wave mode. The SDR is designed to be critically coupled and capable of working with both very lossy samples, such as biological tissues, and non-lossy materials. The SDR was characterized using electromagnetic field simulations, assessed for sensitivity with a B 1 field-perturbation method, and validated with tissue phantoms using EPR measurements. The results showed remarkably higher sensitivity in lossy tissue phantoms than the previously reported multisegment surface-loop resonators. The new SDR can provide potential new insights for advancements in the application of in vivo EPR spectroscopy for biological measurements, including clinical oximetry.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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