Plasma Lipidomic Profiling Identifies Elevated Triglycerides as Potential Risk Factor in Chemotherapy-Induced Peripheral Neuropathy.

Autor:	Yeung N; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Li T; Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.; The University of Sydney, Camperdown, NSW, Australia., Lin HM; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; St Vincent's Clinical School, University of New South Wales, Darlinghurst, NSW, Australia., Timmins HC; Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.; The University of Sydney, Camperdown, NSW, Australia., Goldstein D; Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia., Harrison M; Chris O'Brien Lifehouse, Camperdown, NSW, Australia., Friedlander M; Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia., Mahon KL; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; The University of Sydney, Camperdown, NSW, Australia.; Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Royal Prince Alfred Hospital, Camperdown, NSW, Australia., Giles C; Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Bundoora, VIC, Australia., Meikle PJ; Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Bundoora, VIC, Australia., Park SB; Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia., Horvath LG; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; The University of Sydney, Camperdown, NSW, Australia.; St Vincent's Clinical School, University of New South Wales, Darlinghurst, NSW, Australia.; Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Jazyk:	angličtina
Zdroj:	JCO precision oncology [JCO Precis Oncol] 2024 Apr; Vol. 8, pp. e2300690.
DOI:	10.1200/PO.23.00690
Abstrakt:	Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of cytotoxic cancer treatment, often necessitating dose reduction (DR) or chemotherapy discontinuation (CD). Studies on peripheral neuropathy related to chemotherapy, obesity, and diabetes have implicated lipid metabolism. This study examined the association between circulating lipids and CIPN. Methods: Lipidomic analysis was performed on plasma samples from 137 patients receiving taxane-based treatment. CIPN was graded using Total Neuropathy Score-clinical version (TNSc) and patient-reported outcome measure European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-CIPN (EORTC-QLQ-CIPN20). Results: A significant proportion of elevated baseline lipids were associated with high-grade CIPN defined by TNSc and EORTC-QLQ-CIPN20 including triacylglycerols (TGs). Multivariable Cox regression on lipid species, adjusting for BMI, age, and diabetes, showed several elevated baseline TG associated with shorter time to DR/CD. Latent class analysis identified two baseline lipid profiles with differences in risk of CIPN (hazard ratio, 2.80 [95% CI, 1.50 to 5.23]; P = .0013). The higher risk lipid profile had several elevated TG species and was independently associated with DR/CD when modeled with other clinical factors (diabetes, age, BMI, or prior numbness/tingling). Conclusion: Elevated baseline plasma TG is associated with an increased risk of CIPN development and warrants further validation in other cohorts. Ultimately, this may enable therapeutic intervention.
Databáze:	MEDLINE
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