Plasma pentraxin-3 levels and its role in childhood obesity-Is it anti-inflammatory? A matched group study.

Autor: Uysal M; Department of Public Health, Faculty of Medicine, Cukurova University, Adana, Turkey., Mete B; Department of Public Health, Faculty of Medicine, Cukurova University, Adana, Turkey., Kara E; Department of Public Health, Faculty of Medicine, Cukurova University, Adana, Turkey., Demirhindi H; Department of Public Health, Faculty of Medicine, Cukurova University, Adana, Turkey., Haytoglu Z; Department of General Pediatrics, Faculty of Medicine, Cukurova University, Adana, Turkey., Yuksel B; Department of Pediatrics Endocrinology, Faculty of Medicine, Cukurova University, Adana, Turkey., Turan İ; Department of Pediatrics Endocrinology, Faculty of Medicine, Cukurova University, Adana, Turkey., Daglioglu G; Department of Medical Biochemistry, Faculty of Medicine, Cukurova University, Adana, Turkey., Dogus Y; Department of Medical Biochemistry, Faculty of Medicine, Cukurova University, Adana, Turkey.
Jazyk: angličtina
Zdroj: Clinical endocrinology [Clin Endocrinol (Oxf)] 2024 Jul; Vol. 101 (1), pp. 13-22. Date of Electronic Publication: 2024 May 01.
DOI: 10.1111/cen.15067
Abstrakt: Objective: Obesity has been associated with chronic low-grade systemic inflammation. This study aimed to investigate the relationship of pentraxin-3 (PTX-3) with anthropometric measurements, dietary content and physical activity level in children.
Design: A matched group study.
Patients: This study was conducted with 91 children aged 6-17 years, divided into two groups: "non-obese group" (Body Mass Index Standard Deviation Score [BMI SDS] <95th percentile) and "obese group" (BMI SDS ≥95th percentile).
Measurements: Plasma PTX-3 levels.
Results: The mean age of 91 children included in the study was 12.34 ± 2.86 years. Plasma PTX-3 levels were significantly higher in obese children (p = .028). No significant correlation was found between BMI SDS and plasma PTX-3 values, but a weak positive correlation was found when physical activity level was controlled (r = .176, p = .049). In addition, it was found that fat mass was a partial mediator of plasma PTX-3 level, and an increase in the amount of subcutaneous adipose tissue negatively affected plasma PTX-3 level. Plasma PTX-3 level showed a weak positive correlation (r = .223, p = .017) with physical activity score and dietary polyunsaturated fatty acid intake, while a weak negative correlation with neutrophil-to-lymphocyte ratio. One unit increase in physical activity score or polyunsaturated fatty acid level caused 0.730 and 2.061 unit increases in plasma PTX-3 level, respectively; while one unit increase in dietary fat intake caused 0.413-unit decrease.
Conclusion: There was an indirect relationship between the amount of subcutaneous adipose tissue and PTX-3 level. The results of our study suggested that plasma PTX-3 was associated with lower levels of inflammation in children.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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