Evaluation of salivary stress markers and inflammatory cytokine levels in peri-implantitis patients.

Autor: Soysal F; Department of Periodontology, Faculty of Dentistry, Ankara Medipol University, Ankara, Turkey. soysalfatma@gmail.com., Unsal B; Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkey., Isler SC; Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkey.; Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland., Akca G; Department of Medical Microbiology, Faculty of Dentistry, Gazi University, Ankara, Turkey., Bakirarar B; Department of Biostatistics, Faculty of Medicine, Ankara University, Ankara, Turkey., Ozcan M; Department of Periodontology, Faculty of Dentistry, Cukurova University, Adana, Turkey.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2024 May 01; Vol. 28 (5), pp. 290. Date of Electronic Publication: 2024 May 01.
DOI: 10.1007/s00784-024-05692-5
Abstrakt: Background and Objective: Psychological stress has been identified in some observational studies as a potential factor that may modify and affect periodontal diseases, but there are no similar data for peri-implantitis. The aim of this study was to determine the relationship between interleukin (IL)-1β, IL-6, IL-10, interferon (IFN)α inflammatory cytokines and the psychological stress-related markers, glucocorticoid receptor-α (GRα), and salivary α-amylase (sAA) gene expression levels in saliva samples obtained from healthy implants and peri-implantitis patients.
Materials and Methods: The study included a total of 50 systemically healthy subjects. Peri-implant clinical parameters were recorded and psychological stress level was evaluated with the hospital anxiety and depression scale (HAD) and state-trait anxiety inventory (STAI) questionnaire forms. Following the evaluations, the patients were divided into 4 groups according their stress and clinical status (Ia, Ib, IIa, IIb). IL-1β, IL-6, IL-10, IFNα, GRα, sAA gene expression levels in the saliva samples were quantified by quantitative polymerase chain reaction (qPCR).
Results: In the group of peri-implantitis who had a high score in stress level assessment scales, significantly higher IL-1β, IL-6, sAA expression levels were observed (p < 0.001). The IL-10 gene expression levels were lower in the groups with a high score in the stress level assessment scales (p < 0.001). GRα gene was expressed at lower levels in the group of peri-implantitis who had a high score in stress level assessment scales but the difference was not statistically significant (p = 0.065).
Conclusion: The study findings suggest that psychological stress may increase the inflammation associated with peri-implantitis by affecting cytokine expression levels.
Clinical Relevance: To prevent peri-implantitis or reduce its prevalence, it could be beneficial to evaluate stress levels and identify individuals experiencing stress.
(© 2024. The Author(s).)
Databáze: MEDLINE
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