High-throughput DNA sequence analysis elucidates novel insight into the genetic basis of adaptation in local sheep.

Autor: Asadollahpour Nanaei H; Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, 76169-133, PB, Iran. h.asadollahpour@agr.uk.ac.ir.; Animal Science Research Department, Fars Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education and Extension Organization (AREEO), Shiraz, Iran. h.asadollahpour@agr.uk.ac.ir., Amiri Ghanatsaman Z; Animal Science Research Department, Fars Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education and Extension Organization (AREEO), Shiraz, Iran., Farahvashi MA; Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, 76169-133, PB, Iran., Mousavi SF; Department of Animal Science, Faculty of Agriculture, University of Kurdistan, Sanandaj, Iran., Banabazi MH; Department of Biotechnology, Animal Science Research Institute of IRAN (ASRI) Agricultural Research, Education & Extension Organization (AREEO), 3146618361, Karaj, Iran.; Department of Animal Biosciences (HBIO), Centre for Veterinary Medicine and Animal Science (VHC), Swedish University of Agricultural Sciences (SLU), 75007, Uppsala, Sweden., Asadi Fozi M; Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, 76169-133, PB, Iran. masadi@uk.ac.ir.
Jazyk: angličtina
Zdroj: Tropical animal health and production [Trop Anim Health Prod] 2024 May 01; Vol. 56 (4), pp. 150. Date of Electronic Publication: 2024 May 01.
DOI: 10.1007/s11250-024-04002-1
Abstrakt: Understanding how evolutionary factors related to climate adaptation and human selection have influenced the genetic architecture of domesticated animals is of great interest in biology. In the current study, by using 304 whole genomes from different geographical regions (including Europe, north Africa, Southwest Asia, east Asia, west Africa, south Asia, east Africa, Australia and Turkey), We evaluate global sheep population dynamics in terms of genetic variation and population structure. We further conducted comparative population analysis to study the genetic underpinnings of climate adaption to local environments and also morphological traits. In order to identify genomic signals under selection, we applied fixation index (FST) and also nucleotide diversity (θπ) statistical measurements. Our results revealed several candidate genes on different chromosomes under selection for local climate adaptation (e.g. HOXC12, HOXC13, IRF1, FGD2 and GNAQ), body size (PDGFA, HMGA2, PDE3A) and also morphological related traits (RXFP2). The discovered candidate genes may offer newel insights into genetic underpinning of regional adaptation and commercially significant features in local sheep.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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