Translational validity of neuropsychological tasks of sustained attention between rodents and humans: A systematic review of three rodent tasks.

Autor: Salmon C; Melbourne School of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia., Li S; Melbourne School of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia.; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia., Burrows EL; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia., Johnson KA; Melbourne School of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia.
Jazyk: angličtina
Zdroj: Journal of neurochemistry [J Neurochem] 2024 Sep; Vol. 168 (9), pp. 2170-2189. Date of Electronic Publication: 2024 May 01.
DOI: 10.1111/jnc.16117
Abstrakt: Atypical sustained attention is a symptom in a number of neurological and psychological conditions. Investigations into its neural underpinnings are required for improved management and treatment. Rodents are useful in investigating the neurobiology underlying atypical sustained attention and several rodent tasks have been developed for use in touchscreen testing platforms that mimic methodology used in human clinical attention assessment. This systematic review was conducted to assess how translatable these rodent tasks are to equivalent clinical human tasks. Studies using the rodent Continuous Performance Task (rCPT), Sustained Attention Task (SAT), and 5-choice CPT (5C-CPT) were sought and screened. Included in the review were 138 studies, using the rCPT (n = 21), SAT (n = 90), and 5C-CPT (n = 27). Translatability between rodent and human studies was assessed based on (1) methodological similarity, (2) performance similarity, and (3) replication of results. The 5C-CPT was found to be the most translatable cross-species paradigm with good utility, while the rCPT and SAT require adaptation and further development to meet these translatability benchmarks. With greater replication and more consistent results, greater confidence in the translation of sustained attention results between species will be engendered.
(© 2024 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.)
Databáze: MEDLINE
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