Metabolomic profiling of Medicago sativa -derived fungal endophytes and evaluation of their biological activities.

Autor:	El Amir D; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University 62514 Beni-Suef Egypt dalia.elamir@pharm.bsu.edu.eg., Sayed AM; Department of Pharmacognosy, Collage of Pharmacy, Almaaqal University 61014 Basrah Iraq., El-Hawary SS; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University 11936 Cairo Egypt., Elsakhawy OM; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University 62514 Beni-Suef Egypt dalia.elamir@pharm.bsu.edu.eg., Attia EZ; Department of Pharmacognosy, Faculty of Pharmacy, Minia University 61519 Minia Egypt., Abdelmohsen UR; Department of Pharmacognosy, Faculty of Pharmacy, Minia University 61519 Minia Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University 61111 New Minia Egypt., Mohammed R; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University 62514 Beni-Suef Egypt dalia.elamir@pharm.bsu.edu.eg.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2024 Apr 30; Vol. 14 (20), pp. 14296-14302. Date of Electronic Publication: 2024 Apr 30 (Print Publication: 2024).
DOI:	10.1039/d4ra00790e
Abstrakt:	This study aimed to discover the potential of Medicago sativa -derived fungal endophytes as a prospective source of bioactive metabolites. In the present study, three different strains of fungal endophyte Aspergillus terreus were isolated from leaves L, roots T and stems St of Medicago sativa to explore their biological and chemical diversity. These isolated fungi were exposed to different fermentation conditions by adding various chemical elicitors to their solid fermentation media. According to LC-HRESIMS-based metabolomics and multivariate analysis, each chemical treatment had a different effect on the chemical profiles of the fungi. Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) proposed several compounds with anticancer action against MCF-7 (a human breast cancer cell line) and MDA-MB-231 (a human epithelial breast cancer cell line). Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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