Echocardiographic characterization of age- and sex-associated differences in cardiac function and morphometry in nonhuman primates.

Autor: Florio MC; Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute On Aging, NIH, Baltimore, MD, USA. cristiflorio@gmail.com., Fusini L; Department of Cardiovascular Imaging, Centro Cardiologico Monzino - IRCCS, Milan, Italy., Tamborini G; Department of Cardiovascular Imaging, Centro Cardiologico Monzino - IRCCS, Milan, Italy., Morrell C; Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute On Aging, NIH, Baltimore, MD, USA., McDonald A; Division of Cardiology, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA., Walcott M; Division of Cardiology, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA., Ridley K; Division of Cardiology, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA., Vaughan KL; Translational Gerontology Branch, National Institute on Aging, NIH Animal Center, Dickerson, MD, USA., Mattison JA; Translational Gerontology Branch, National Institute on Aging, NIH Animal Center, Dickerson, MD, USA., Pepi M; Department of Cardiovascular Imaging, Centro Cardiologico Monzino - IRCCS, Milan, Italy., Lakatta EG; Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute On Aging, NIH, Baltimore, MD, USA., Capogrossi MC; Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute On Aging, NIH, Baltimore, MD, USA. mcapogr1@jhmi.edu.; Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. mcapogr1@jhmi.edu.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2024 Oct; Vol. 46 (5), pp. 4615-4634. Date of Electronic Publication: 2024 Apr 30.
DOI: 10.1007/s11357-024-01172-6
Abstrakt: Aging per se is a major risk factor for cardiovascular diseases and is associated with progressive changes in cardiac structure and function. Rodent models are commonly used to study cardiac aging, but do not closely mirror differences as they occur in humans. Therefore, we performed a 2D echocardiographic study in non-human primates (NHP) to establish age- and sex-associated differences in cardiac function and morphometry in this animal model. M mode and 2D echocardiography and Doppler analyses were performed cross-sectionally in 38 healthy rhesus monkeys (20 females and 18 males), both young (age 7-12 years; n = 20) and old (age 19-30 years; n = 18). The diameters of the cardiac chambers did not differ significantly by age group, but males had larger left ventricular diameters (2.43 vs 2.06 cm in diastole and 1.91 vs 1.49 cm in systole, p = 0.0004 and p = 0.0001, respectively) and left atrial diameter (1.981 vs 1.732 cm; p = 0.0101). Left ventricular mass/body surface area did not vary significantly with age and sex. Ejection fraction did not differ by age and females presented a higher ejection fraction than males (54.0 vs 50.8%, p = 0.0237). Diastolic function, defined by early to late mitral peak flow velocity ratio (E/A), was significantly lower in old rhesus monkeys (2.31 vs 1.43, p = 0.0020) and was lower in females compared to males (1.595 vs 2.230, p = 0.0406). Right ventricular function, evaluated by measuring the Tricuspid Annular Plane Systolic Excursion, did not differ by age or sex, and Right Ventricular Free Wall Longitudinal Strain, did not differ with age but was lower in males than in females (-22.21 vs -17.95%, p = 0.0059). This is the first echocardiographic study to evaluate age- and sex-associated changes of cardiac morphometry and function in young and old NHP. The findings of this work will provide a reference to examine the effect of age and sex on cardiac diseases in NHP.
(© 2024. The Author(s), under exclusive licence to American Aging Association.)
Databáze: MEDLINE
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