Fundamentals of redox regulation in biology.

Autor: Sies H; Institute for Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. sies@hhu.de.; Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. sies@hhu.de., Mailloux RJ; School of Human Nutrition, Faculty of Agricultural and Environmental Science, McGill University, Sainte-Anne-de-Bellevue, Quebec, Canada. ryan.mailloux@mcgill.ca., Jakob U; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. ujakob@umich.edu.; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA. ujakob@umich.edu.
Jazyk: angličtina
Zdroj: Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2024 Sep; Vol. 25 (9), pp. 701-719. Date of Electronic Publication: 2024 Apr 30.
DOI: 10.1038/s41580-024-00730-2
Abstrakt: Oxidation-reduction (redox) reactions are central to the existence of life. Reactive species of oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular processes. Yet, excessive levels of oxidants are associated with ageing and many diseases, including cardiological and neurodegenerative diseases, and cancer. Hence, maintaining the fine-tuned steady-state balance of reactive species production and removal is essential. Here, we discuss new insights into the dynamic maintenance of redox homeostasis (that is, redox homeodynamics) and the principles underlying biological redox organization, termed the 'redox code'. We survey how redox changes result in stress responses by hormesis mechanisms, and how the lifelong cumulative exposure to environmental agents, termed the 'exposome', is communicated to cells through redox signals. Better understanding of the molecular and cellular basis of redox biology will guide novel redox medicine approaches aimed at preventing and treating diseases associated with disturbed redox regulation.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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