Adaptive patterning of vascular network during avian skin development: Mesenchymal plasticity and dermal vasculogenesis.

Autor: Ou KL; Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America; Ostrow School of Dentistry of the University of Southern California, Los Angeles, CA, United States of America; Burn Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan., Chen CK; Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America., Huang JJ; Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA, United States of America; Graduate Programs in Biomedical and Biological Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America., Chang WW; Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America; Integrative Stem Cell Center, China Medical University, Taichung, Taiwan; Institute of Physiology, Christian-Albrechts-Universität zu Kiel, Kiel, Germany., Hsieh Li SM; Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America; Ostrow School of Dentistry of the University of Southern California, Los Angeles, CA, United States of America., Jiang TX; Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America., Widelitz RB; Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America., Lansford R; Department of Radiology and Developmental Neuroscience Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, United States of America; Department of Radiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America., Chuong CM; Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America. Electronic address: cmchuong@med.usc.edu.
Jazyk: angličtina
Zdroj: Cells & development [Cells Dev] 2024 Sep; Vol. 179, pp. 203922. Date of Electronic Publication: 2024 Apr 28.
DOI: 10.1016/j.cdev.2024.203922
Abstrakt: A vasculature network supplies blood to feather buds in the developing skin. Does the vasculature network during early skin development form by sequential sprouting from the central vasculature or does local vasculogenesis occur first that then connect with the central vascular tree? Using transgenic Japanese quail Tg(TIE1p.H2B-eYFP), we observe that vascular progenitor cells appear after feather primordia formation. The vasculature then radiates out from each bud and connects with primordial vessels from neighboring buds. Later they connect with the central vasculature. Epithelial-mesenchymal recombination shows local vasculature is patterned by the epithelium, which expresses FGF2 and VEGF. Perturbing noggin expression leads to abnormal vascularization. To study endothelial origin, we compare transcriptomes of TIE1p.H2B-eYFP + cells collected from the skin and aorta. Endothelial cells from the skin more closely resemble skin dermal cells than those from the aorta. The results show developing chicken skin vasculature is assembled by (1) physiological vasculogenesis from the peripheral tissue, and (2) subsequently connects with the central vasculature. The work implies mesenchymal plasticity and convergent differentiation play significant roles in development, and such processes may be re-activated during adult regeneration. SUMMARY STATEMENT: We show the vasculature network in the chicken skin is assembled using existing feather buds as the template, and endothelia are derived from local bud dermis and central vasculature.
Competing Interests: Declaration of competing interest The authors declare no competing financial interests.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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