Direct-Acting Oral Anticoagulant/Vitamin K Antagonists: Do They Affect the Trabecular and Cortical Structure of the Mandible?

Autor:	Bostan SA; Recep Tayyip Erdoğan University, Faculty of Dentistry, Department of Periodontology, Rize, Turkey., Özarslantürk S; University of Health Sciences, Gulhane Faculty of Dental Medicine, Department of Dentomaxillofacial Radiology, Ankara, Turkey., Günaçar DN; Recep Tayyip Erdoğan University, Faculty of Dentistry, Department of Dentomaxillofacial Radiology, Rize, Turkey., Gonca M; Recep Tayyip Erdoğan University, Faculty of Dentistry, Department of Orthodontics, Rize, Turkey., Göller Bulut D; Bolu Abant İzzet Baysal University, Faculty of Dentistry, Department of Dentomaxillofacial Radiology, Bolu, Turkey., Ok Bostan H; Recep Tayyip Erdoğan University, Faculty of Dentistry, Department of Prosthodontics, Rize, Turkey. Electronic address: hilalokbostan08@gmail.com.
Jazyk:	angličtina
Zdroj:	Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry [J Clin Densitom] 2024 Jul-Sep; Vol. 27 (3), pp. 101495. Date of Electronic Publication: 2024 Apr 16.
DOI:	10.1016/j.jocd.2024.101495
Abstrakt:	Background: This study aimed to evaluate the mandibular bone structure of patients using oral anticoagulants (OACs) vitamin K antagonist drugs (warfarin) and other OACs including direct oral anticoagulants [(DOACs) apixaban, rivaroxaban, dabigatran, edoxaban]. Analyses were based upon the fractal dimension (FD), the panoramic mandibular index (PMI) and the Klemetti index (KI), which is also known as the mandibular cortical index (MCI). Methodology: Ninety participants were divided into three groups: group 1: 30 systemically healthy individuals who had not used any anticoagulants before, group 2: 30 individuals using warfarin, and group 3: 30 individuals using DOACs. FD was used to analyze trabecular bone architecture in the condyle, angle, and two sites in the alveolar bone. PMI was used to evaluate the quantity of cortical bone and KI was used to evaluate the cortical bone quality. Results: There was no difference between the groups regarding FD analysis and KI; however, a difference was found between groups 1, 2, and 3 in the PMI (P≤ 0.001). The PMI in group 1 was higher than in groups 2 and 3. Conclusion: Mandibular radiomorphometric indices can be used on panoramic radiographs to evaluate the quantity of mandibular cortical bone in patients using oral anticoagulants. Competing Interests: Conflicts of interest The authors declare that they have no conflict of interest. (Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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