Association between prognosis and lymph node status using 18 F-fluorodeoxyglucose-positron emission tomography in esophageal squamous cell carcinoma treated with esophagectomy post-neoadjuvant chemotherapy.

Autor: Ohsawa M; Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan., Hamai Y; Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan., Emi M; Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan., Ibuki Y; Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan., Kurokawa T; Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan., Yoshikawa T; Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan., Hirohata R; Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan., Kitasaki N; Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan., Okada M; Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan.
Jazyk: angličtina
Zdroj: World journal of surgery [World J Surg] 2024 Mar; Vol. 48 (3), pp. 650-661. Date of Electronic Publication: 2024 Jan 23.
DOI: 10.1002/wjs.12067
Abstrakt: Background: There are few reports on the associations between lymph node (LN) status, determined by preoperative 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET), and prognosis in patients with locally advanced esophageal squamous cell carcinoma (ESCC) who underwent esophagectomy post-neoadjuvant chemotherapy (NCT). Additionally, details on the diagnostic performance of LN metastasis determination based on pathological examination versus FDG-PET have not been reported. In this study, we aimed to evaluate the associations among LN status using FDG-PET, LN status based on pathological examination, and prognosis in patients with locally advanced ESCC who underwent esophagectomy post-NCT.
Methods: We reviewed the data of 124 consecutive patients with ESCC who underwent esophagectomy with R0 resection post-NCT between December 2008 and August 2022 and were evaluated pre- and post-NCT using FDG-PET. The associations among LN status using FDG-PET, LN status based on pathological examination, and prognosis were assessed.
Results: Station-by-station analysis of PET-positive LNs pre- and post-NCT correlated significantly with pathological LN metastases (sensitivity, specificity, and accuracy pre- and post-NCT: 51.6%, 96.0%, and 92.1%; and 28.2%, 99.5%, and 93.1%, respectively; both p < 0.0001). Using univariate and multivariate analyses, LN status determined using PET post-NCT was a significant independent predictor of both recurrence-free survival and overall survival.
Conclusion: The LN status assessed using FDG-PET post-NCT was significantly associated with the pathological LN status and prognosis in patients with ESCC who underwent esophagectomy post-NCT. Therefore, FDG-PET is a useful diagnostic tool for preoperatively predicting pathological LN metastasis and survival in these patients and could provide valuable information for selecting individualized treatment strategies.
(© 2024 International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).)
Databáze: MEDLINE
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