Long term survival outcomes of surgery combined with hyperthermic intraperitoneal chemotherapy for perforated low-grade appendiceal mucinous neoplasms: A multicenter retrospective study.

Autor: Han Z; Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Liu X; Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Tian Y; Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Shen S; Department of Colorectal Surgery, Weifang People's Hospital, Weifang, Shandong, China., Wang H; Department of Gastrointestinal Surgery, The People's Hospital of Jimo Qingdao, Qingdao, Shandong, China., Hu S; Department of Gastrointestinal Surgery, The People's Hospital of Jimo Qingdao, Qingdao, Shandong, China., Wu X; Department of Gastrointestinal Surgery, The People's Hospital of Dongying Shandong, Dongying, Shandong, China., Yan Z; Department of Gastrointestinal Surgery, The People's Hospital of Dongying Shandong, Dongying, Shandong, China., Lu C; Department of Gastrointestinal Surgery, Juxian People's Hospital, Rizhao, Shandong, China., Wang P; General Surgery Department, Qingdao Hospital University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, Shandong, China., Bai Y; General Surgery Department, 971st Naval Hospital, Qingdao, Shandong, China., Kong Y; General Surgery Department, Jining No 1 People's Hospital, Jining, Shandong, China., Wang L; Department of Gastrointestinal Surgery, Weifang Yidu Central Hospital, Weifang, Shandong, China., Cao S; Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Li Z; Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Zhong H; Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Meng C; Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Zhou Y; Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Jazyk: angličtina
Zdroj: World journal of surgery [World J Surg] 2024 Jan; Vol. 48 (1), pp. 86-96. Date of Electronic Publication: 2023 Dec 14.
DOI: 10.1002/wjs.12018
Abstrakt: Background: Low-grade appendiceal mucinous neoplasms (LAMN) are very rare, accounting for approximately 0.2%-0.5% of gastrointestinal tumors. We conducted a multicenter retrospective study to explore the impact of different surgical procedures combined with HIPEC on the short-term outcomes and long-term survival of patients.
Methods: We retrospectively analyzed the clinicopathological data of 91 LAMN perforation patients from 9 teaching hospitals over a 10-year period, and divided them into HIPEC group and non-HIPEC group based on whether or not underwent HIPEC.
Results: Of the 91 patients with LAMN, 52 were in the HIPEC group and 39 in the non-HIPEC group. The Kaplan-Meier method predicted that 52 patients in the HIPEC group had 5- and 10-year overall survival rates of 82.7% and 76.9%, respectively, compared with predicted survival rates of 51.3% and 46.2% for the 39 patients in the non-HIPEC group, with a statistically significant difference between the two groups (χ 2  = 10.622, p = 0.001; χ 2  = 10.995, p = 0.001). Compared to the 5-year and 10-year relapse-free survival rates of 75.0% and 65.4% in the HIPEC group, respectively, the 5-year and 10-year relapse-free survival rates of 48.7% and 46.2% in the non-HIPEC group were significant different between the two outcomes (χ 2  = 8.063, p = 0.005; χ 2  = 6.775, p = 0.009). The incidence of postoperative electrolyte disturbances and hypoalbuminemia was significantly higher in the HIPEC group than in the non-HIPEC group (p = 0.023; p = 0.044).
Conclusions: This study shows that surgery combined with HIPEC can significantly improve 5-year and 10-year overall survival rates and relapse-free survival rates of LAMN perforation patients, without affecting their short-term clinical outcomes.
(© 2023 International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).)
Databáze: MEDLINE
Externí odkaz: