From Sugar Spikes to Pressure Peaks: Navigating the World of Diabetes, Hypertension, Obesity, and Kidney Health.

Autor:	Hlyan NP; General Surgery, Barts Health National Health Service (NHS) Trust, London, GBR., Arif T; Accident and Emergency, Imran Idrees Teaching Hospital, Sialkot, PAK., Jaufar SS; Family Medicine and General Surgery, Vitebsk State Medical University, Vitebsk, BLR., Rehman A; Surgery, Mayo Hospital, Lahore, PAK., Ayalew BD; Internal Medicine, St. Paul's Hospital Millennium Medical College, Addis Ababa, ETH., Batu BJ; General Practice, St. Paul's Hospital Millennium Medical College, Addis Ababa, ETH., Hundesa MI; General Practice, Ministry of Health, Addis Ababa, ETH., Hlaing MS; Geriatrics, United Lincolnshire Hospitals National Health Service (NHS) Trust, Boston, GBR., Islam H; Internal Medicine, Punjab Medical College, Faisalabad, PAK., Islam R; Research, Faisalabad Medical University, Faisalabad, PAK., Shehryar A; Internal Medicine, Allama Iqbal Medical College, Lahore, PAK., Quinn M; Internal Medicine, Jinnah Hospital, Lahore, PAK.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Mar 30; Vol. 16 (3), pp. e57241. Date of Electronic Publication: 2024 Mar 30 (Print Publication: 2024).
DOI:	10.7759/cureus.57241
Abstrakt:	Diabetes, hypertension, obesity, and chronic kidney disease (CKD) are major public health challenges globally, contributing significantly to morbidity and mortality. The co-occurrence and interplay among these conditions exacerbate health outcomes, highlighting the need for an integrated understanding and approach to management. This narrative review aims to explore the complex relationships between diabetes, hypertension, obesity, and CKD, elucidating their collective impact on health. It discusses the epidemiological trends, underlying pathophysiological mechanisms, genetic predispositions, current treatment strategies, and the future direction of research and therapy. An extensive review of current literature was conducted, focusing on the epidemiology, pathophysiology, risk factors, diagnosis, and treatment of diabetes, hypertension, obesity, and CKD. Additionally, the review delves into the genetic and molecular biology underlying these conditions, the potential for personalized medicine, and the importance of a multidisciplinary approach to care. The review identifies key areas where these conditions intersect, enhancing disease progression and complicating management. It highlights the role of genetic and environmental factors in disease etiology, the critical need for personalized treatment strategies, and the gaps in current management approaches. Innovations in pharmacotherapy, monitoring technologies, and the potential of pharmacogenomics are discussed as avenues for advancing patient care. Diabetes, hypertension, obesity, and CKD are intricately linked, necessitating an integrated, patient-centered approach to care that goes beyond traditional treatment modalities. Future research should focus on collaborative models and interdisciplinary strategies to address the multifaceted challenges posed by these conditions. Emphasizing personalized medicine and leveraging technological advancements offer promising pathways to improve outcomes and reduce the global health burden of these metabolic disorders. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Hlyan et al.)
Databáze:	MEDLINE
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