Cardiac Challenges in Immune Checkpoint Therapy: Complete Heart Block With Pembrolizumab.
| Autor: | Sabanci R; Internal Medicine, Michigan State University, East Lansing, USA., Saeed M; Internal Medicine, Michigan State University, East Lansing, USA., Watat K; Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA., Kim AG; Internal Medicine, Michigan State University, East Lansing, USA., Shaban D; Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA., Nader G; Internal Medicine, Bronx Care, New York, USA.; Internal Medicine, Michigan State Sparrow Hospital, Lansing, USA., Ghnaima H; Internal Medicine, Michigan State University, East Lansing, USA., Wilcox M; Cardiology, Sparrow Hospital Thoracic and Cardiovascular Institute, Lansing, USA., Ali-Ahmed F; Electrophysiology, Sparrow Hospital Thoracic and Cardiovascular Institute, Lansing, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Mar 30; Vol. 16 (3), pp. e57244. Date of Electronic Publication: 2024 Mar 30 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.57244 |
| Abstrakt: | Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, yet they come with a spectrum of immune-related adverse events, including cardiac complications. We present the case of a 72-year-old male with metastatic renal cell carcinoma who developed complete heart block and ventricular arrhythmias following pembrolizumab therapy. Despite no evidence of myocarditis, the patient's condition rapidly deteriorated, ultimately resulting in his demise. This case underscores the critical need for vigilance in recognizing and managing potential cardiotoxicity associated with ICIs. Additionally, it highlights the importance of multidisciplinary collaboration in optimizing diagnostic and therapeutic strategies for patients undergoing immune checkpoint inhibitor therapy. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Sabanci et al.) |
| Databáze: | MEDLINE |
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