Impact of serum leptin and adiponectin levels on brain infarcts in patients with mild cognitive impairment and Alzheimer's disease: a longitudinal analysis.

Autor:	Carbone G; Department of Translational Medical Sciences, 'Federico II' University, Naples, Italy., Bencivenga L; Department of Translational Medical Sciences, 'Federico II' University, Naples, Italy., Santoro MA; Department of Translational Medical Sciences, 'Federico II' University, Naples, Italy., De Lucia N; Department of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy., Palaia ME; Department of Translational Medical Sciences, 'Federico II' University, Naples, Italy., Ercolano E; Department of Translational Medical Sciences, 'Federico II' University, Naples, Italy., Scognamiglio F; Department of Translational Medical Sciences, 'Federico II' University, Naples, Italy., Edison P; Department of Brain Sciences, Imperial College London, London, United Kingdom., Ferrara N; Department of Translational Medical Sciences, 'Federico II' University, Naples, Italy., Vitale DF; Clinica San Michele, Maddaloni, CE, Italy., Rengo G; Department of Translational Medical Sciences, 'Federico II' University, Naples, Italy.; Laboratorio di fisiopatologia del sistema neurovegetativo, Istituti Clinici Scientifici Maugeri Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) - Scientific Institute of Telese Terme, Telese Terme, BN, Italy., Femminella GD; Department of Translational Medical Sciences, 'Federico II' University, Naples, Italy.; Department of Brain Sciences, Imperial College London, London, United Kingdom.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Apr 15; Vol. 15, pp. 1389014. Date of Electronic Publication: 2024 Apr 15 (Print Publication: 2024).
DOI:	10.3389/fendo.2024.1389014
Abstrakt:	Introduction: The adipokines leptin and adiponectin have been associated with atherosclerosis and the risk of cerebral infarcts. Pre-clinical studies, however, suggest a protective role against ischemic brain damage. In this study we analyzed the relationship between serum leptin and adiponectin levels and the onset or progression of brain infarcts in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Methods: All data were extracted from the ADNI database. The final population included 566 subjects, with 58 healthy controls, 396 MCI and 112 AD. All patients with available serum leptin and adiponectin levels at baseline were selected. Demographics, neuropsychological test results, CSF biomarkers, regional brain metabolism with FDG-PET data and the number of brain infarcts on longitudinal MRI scans were extracted. Results: Leptin levels were significantly lower in patients with MCI than controls at baseline, while adiponectin levels were not different between the groups. Multivariate logistic regression analysis at baseline for the presence of brain infarcts showed a predictive value for leptin but not for adiponectin. Multivariate longitudinal analysis showed that age was the only significant predictor of brain infarcts development at 15-year follow-up, while serum leptin and adiponectin levels did not play a role in this population. Discussion: The evidence on the pathogenetic or protective role of adipokines on ischemic brain damage is mixed. In this MCI and AD population, serum leptin and adiponectin were not associated with the development of brain infarcts; therefore, these results do not support the use of adipokines as biomarkers of cerebrovascular pathology in this population. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision (Copyright © 2024 Carbone, Bencivenga, Santoro, De Lucia, Palaia, Ercolano, Scognamiglio, Edison, Ferrara, Vitale, Rengo and Femminella.)
Databáze:	MEDLINE
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