Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (IRCC).

Autor: Saberzadeh-Ardestani B; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Khosravi AA; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Mansour-Ghanaei F; Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Guilan, Iran., Vahedi H; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Baniasadi N; Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran., Seyyedmajidi M; Golestan Research Center of Gastroenterology, Golestan University of Medical Science, Gorgan, Iran., Parhizkar B; Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran., Hormati A; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Naghshbandi SJ; Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran., Matin S; Department of Internal Medicine, School of Medicine, Lung Diseases Research Center, Ardabil, Iran.; Digestive Diseases Research Center, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran., Hassan Zadeh AA; Nazeran Hospital, Mashhad, Iran., Taghvaei T; Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran., Bahrami M; Sasan Alborz Biomedical Research Center, Masoud Gastroenterology and Hepatology Center, Tehran, Iran., Rafeey M; Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Ahadi M; Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashhad, Iran., Vossoughinia H; Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashhad, Iran., Muosavi H; Sasan Alborz Biomedical Research Center, Masoud Gastroenterology and Hepatology Center, Tehran, Iran., Gheibi S; Maternal and Childhood Obesity Research center, Urmia University of Medical Sciences, Urmia, Iran., Hosseini-Hemmatabadi RS; Shahid Sadoughi University, Yazd, Iran., Yazdanbod A; Digestive Disease Research Center, Ardabil University of Medical Science, Ardabil, Iran., Matinkhah S; Isfahan University of Medical Sciences, Isfahan, Iran., Sheikh Esmaeili F; Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran., Fakheri H; Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran., Moosavy SH; Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran., Maleki I; Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran., Nasseri-Moghaddam S; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Khosravi B; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Farahmand F; Pediatric Gastroenterology and Hepatology in Children Research Center, Tehran University of Medical Sciences, Tehran, Iran., Najafi M; Tehran University of Medical Sciences, Tehran, Iran., Alimadadi H; Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran., Malekzadeh M; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Anushiravani A; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Kasaeian A; Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.; Research Center for Chronic Inflammatory Diseases, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.; Clinical Research Development Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran., Alatab S; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Sadeghi A; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Radmard AR; Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran., Kolahdoozan S; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Rajabi Z; Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran., Sima AR; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.; Sasan Alborz Biomedical Research Center, Masoud Gastroenterology and Hepatology Center, Tehran, Iran.
Jazyk: angličtina
Zdroj: Archives of Iranian medicine [Arch Iran Med] 2024 Apr 01; Vol. 27 (4), pp. 183-190. Date of Electronic Publication: 2024 Apr 01.
DOI: 10.34172/aim.2024.27
Abstrakt: Background: Data on the epidemiology of inflammatory bowel disease (IBD) in the Middle East are scarce. We aimed to describe the clinical phenotype, disease course, and medication usage of IBD cases from Iran in the Middle East.
Methods: We conducted a cross-sectional study of registered IBD patients in the Iranian Registry of Crohn's and Colitis (IRCC) from 2017 until 2022. We collected information on demographic characteristics, past medical history, family history, disease extent and location, extra-intestinal manifestations, IBD medications, and activity using the IBD-control-8 questionnaire and the Manitoba IBD index, admissions history, history of colon cancer, and IBD-related surgeries.
Results: In total, 9746 patients with ulcerative colitis (UC) (n=7793), and Crohn's disease (CD) (n=1953) were reported. The UC to CD ratio was 3.99. The median age at diagnosis was 29.2 (IQR: 22.6,37.6) and 27.6 (IQR: 20.6,37.6) for patients with UC and CD, respectively. The male-to-female ratio was 1.28 in CD patients. A positive family history was observed in 17.9% of UC patients. The majority of UC patients had pancolitis (47%). Ileocolonic involvement was the most common type of involvement in CD patients (43.7%), and the prevalence of stricturing behavior was 4.6%. A prevalence of 0.3% was observed for colorectal cancer among patients with UC. Moreover,15.2% of UC patients and 38.4% of CD patients had been treated with anti-tumor necrosis factor (anti-TNF).
Conclusion: In this national registry-based study, there are significant differences in some clinical phenotypes such as the prevalence of extra-intestinal manifestations and treatment strategies such as biological use in different geographical locations.
(© 2024 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.)
Databáze: MEDLINE
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