Engineering is evolution: a perspective on design processes to engineer biology.

Autor: Castle SD; School of Biological Sciences, University of Bristol, Life Sciences Building, 24 Tyndall Avenue, Bristol, UK. s.castle@bristol.ac.uk., Stock M; KERMIT, Department of Data Analysis and Mathematical Modelling, Ghent University, Ghent, Belgium., Gorochowski TE; School of Biological Sciences, University of Bristol, Life Sciences Building, 24 Tyndall Avenue, Bristol, UK. thomas.gorochowski@bristol.ac.uk.; BrisEngBio, School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK. thomas.gorochowski@bristol.ac.uk.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Apr 29; Vol. 15 (1), pp. 3640. Date of Electronic Publication: 2024 Apr 29.
DOI: 10.1038/s41467-024-48000-1
Abstrakt: Careful consideration of how we approach design is crucial to all areas of biotechnology. However, choosing or developing an effective design methodology is not always easy as biology, unlike most areas of engineering, is able to adapt and evolve. Here, we put forward that design and evolution follow a similar cyclic process and therefore all design methods, including traditional design, directed evolution, and even random trial and error, exist within an evolutionary design spectrum. This contrasts with conventional views that often place these methods at odds and provides a valuable framework for unifying engineering approaches for challenging biological design problems.
(© 2024. The Author(s).)
Databáze: MEDLINE
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