Metabolomic insights in advanced cardiomyopathy of chronic chagasic and idiopathic patients that underwent heart transplant.

Autor: de Oliveira RM; School of Medicine, University of Brasilia, Brasilia, Brazil.; Laboratory of Protein Chemistry and Biochemistry, University of Brasilia, Brasilia, Brazil., Paiva MUB; School of Medicine, University of Brasilia, Brasilia, Brazil., Picossi CRC; Center of Excellence in Metabolomics and Bioanalysis, University of San Pablo CEU, Madrid, Spain., Paiva DVN; School of Medicine, University of Brasilia, Brasilia, Brazil., Ricart CAO; Laboratory of Protein Chemistry and Biochemistry, University of Brasilia, Brasilia, Brazil., Ruperez FJ; Center of Excellence in Metabolomics and Bioanalysis, University of San Pablo CEU, Madrid, Spain., Barbas C; Center of Excellence in Metabolomics and Bioanalysis, University of San Pablo CEU, Madrid, Spain., Atik FA; School of Medicine, University of Brasilia, Brasilia, Brazil.; Institute of Cardiology and Transplantation of the Federal District, Brasilia, Brazil., Martins AMA; School of Medicine, University of Brasilia, Brasilia, Brazil. alin3.m4rtins@gmail.com.; Center of Excellence in Metabolomics and Bioanalysis, University of San Pablo CEU, Madrid, Spain. alin3.m4rtins@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Apr 29; Vol. 14 (1), pp. 9810. Date of Electronic Publication: 2024 Apr 29.
DOI: 10.1038/s41598-024-53875-7
Abstrakt: Heart failure (HF) studies typically focus on ischemic and idiopathic heart diseases. Chronic chagasic cardiomyopathy (CCC) is a progressive degenerative inflammatory condition highly prevalent in Latin America that leads to a disturbance of cardiac conduction system. Despite its clinical and epidemiological importance, CCC molecular pathogenesis is poorly understood. Here we characterize and discriminate the plasma metabolomic profile of 15 patients with advanced HF referred for heart transplantation - 8 patients with CCC and 7 with idiopathic dilated cardiomyopathy (IDC) - using gas chromatography/quadrupole time-of-flight mass spectrometry. Compared to the 12 heart donor individuals, also included to represent the control (CTRL) scenario, patients with advanced HF exhibited a metabolic imbalance with 21 discriminating metabolites, mostly indicative of accumulation of fatty acids, amino acids and important components of the tricarboxylic acid (TCA) cycle. CCC vs. IDC analyses revealed a metabolic disparity between conditions, with 12 CCC distinctive metabolites vs. 11 IDC representative metabolites. Disturbances were mainly related to amino acid metabolism profile. Although mitochondrial dysfunction and loss of metabolic flexibility may be a central mechanistic event in advanced HF, metabolic imbalance differs between CCC and IDC populations, possibly explaining the dissimilar clinical course of Chagas' patients.
(© 2024. The Author(s).)
Databáze: MEDLINE
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