Sex-Specific Differences in Patients with IDH1 -Wild-Type Grade 4 Glioma in the ReSPOND Consortium.

Autor:	Gongala S; From the Department of Radiology (S.G., N.K., J.S., C.T., C.B.), Case Western Reserve University School of Medicine, Cleveland, Ohio.; Department of Radiology (S.G., N.K., C.T., C.B.), University Hospitals of Cleveland, Cleveland, Ohio., Garcia JA; Center for Biomedical Image Computing and Analytics (CBICA) (J.A.G., C.D.), University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Radiology (J.A.G., S.M., C.D.), Division of Neuroradiology at the University of Pennsylvania, Philadelphia, Pennsylvania., Korakavi N; From the Department of Radiology (S.G., N.K., J.S., C.T., C.B.), Case Western Reserve University School of Medicine, Cleveland, Ohio.; Department of Radiology (S.G., N.K., C.T., C.B.), University Hospitals of Cleveland, Cleveland, Ohio., Patil N; Department of Population and Quantitative Health Sciences (N.P.), Case Western Reserve University School of Medicine, Cleveland, Ohio.; University Hospitals Health System (N.P.), Research and Education Institute, Cleveland, Ohio., Akbari H; Department of Bioengineering (H.A.), Santa Clara University, Santa Clara, California., Sloan A; Neuroscience Service line (A.Sloan), Department of Neurosurgery, Piedmont Health, Atlanta, Georgia.; Department of Cancer Biology (A.Sloan), Case Comprehensive Cancer Center, Cleveland, Ohio., Barnholtz-Sloan JS; Center for Biomedical Informatics and Information Technology (J.S.B.-S.), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.; Trans-Divisional Research Program (J.S.B.-S.), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., Sun J; From the Department of Radiology (S.G., N.K., J.S., C.T., C.B.), Case Western Reserve University School of Medicine, Cleveland, Ohio., Griffith B; Department of Radiology (B.G.), Henry Ford Health, Detroit, Michigan., Poisson LM; Department of Radiology (L.M.P.), Wayne State University School of Medicine Henry Ford, Detroit, Michigan., Booth TC; School of Biomedical Engineering & Imaging Sciences (L.M.P.), King's College London, London, United Kingdom.; Department of Neuroradiology (L.M.P.), King's College Hospital NHS Foundation Trust, London, United Kingdom., Jain R; Departments of Radiology and Neurosurgery (R.J., M.P.N.), New York University Langone Health, New York, New York., Mohan S; Department of Radiology (J.A.G., S.M., C.D.), Division of Neuroradiology at the University of Pennsylvania, Philadelphia, Pennsylvania., Nasralla MP; Center for AI and Data Science for Integrated Diagnostics (C.D), at the University of Pennsylvania, Philadelphia, Pennsylvania.; Departments of Radiology and Neurosurgery (R.J., M.P.N.), New York University Langone Health, New York, New York.; Department of Pathology and Laboratory Medicine (M.P.N.), at the University of Pennsylvania, Philadelphia, Pennsylvania.; Glioblastoma Translational Center of Excellence, Abramson Cancer Center (M.P.N.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Bakas S; Division of Computational Pathology (S.B.), Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana.; Department of Radiology and Imaging Sciences (S.B.), Indiana University, Indianapolis, Indiana.; Department of Neurological Surgery (S.B.), School of Medicine, Indiana University, Indianapolis, Indiana, Indiana University, Indianapolis, Indiana., Tippareddy C; From the Department of Radiology (S.G., N.K., J.S., C.T., C.B.), Case Western Reserve University School of Medicine, Cleveland, Ohio.; Department of Radiology (S.G., N.K., C.T., C.B.), University Hospitals of Cleveland, Cleveland, Ohio., Puig J; Radiology Department CDI (J.P.), Hospital Clinic of Barcelona, Barcelona, Spain., Palmer JD; Department of Radiation Oncology and Neurosurgery (J.D.P.), The James Cancer Hospital at the Ohio State University Wexner Medical Center, Columbus, Ohio., Shi W; Department of Radiation Oncology (W.S.), Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Colen RR; Department of Radiology (R.R.C.), University of Pittsburgh, Pittsburgh, Pennsylvania.; Hillman Cancer Center (R.R.C.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania., Sotiras A; Department of Radiology (A.Sotiras), WA University School of Medicine, St. Louis, Missouri.; Institute for Informatics (A.Sotiras), Data Science & Biostatistics, Washington University School of Medicine, St. Louis, Missouri., Ahn SS; Department of Radiology (S.S.A., Y.W.P.), Section of Neuroradiology, Yonsei University Health System, Seoul, Republic of Korea., Park YW; Department of Radiology (S.S.A., Y.W.P.), Section of Neuroradiology, Yonsei University Health System, Seoul, Republic of Korea.; Department of Radiology (J.A.G., S.M., C.D.), Division of Neuroradiology at the University of Pennsylvania, Philadelphia, Pennsylvania., Davatzikos C; Center for Biomedical Image Computing and Analytics (CBICA) (J.A.G., C.D.), University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Radiology (J.A.G., S.M., C.D.), Division of Neuroradiology at the University of Pennsylvania, Philadelphia, Pennsylvania.; Center for AI and Data Science for Integrated Diagnostics (C.D), at the University of Pennsylvania, Philadelphia, Pennsylvania., Badve C; From the Department of Radiology (S.G., N.K., J.S., C.T., C.B.), Case Western Reserve University School of Medicine, Cleveland, Ohio cab231@case.edu.; Department of Radiology (S.G., N.K., C.T., C.B.), University Hospitals of Cleveland, Cleveland, Ohio.
Jazyk:	angličtina
Zdroj:	AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2024 Sep 09; Vol. 45 (9), pp. 1299-1307. Date of Electronic Publication: 2024 Sep 09.
DOI:	10.3174/ajnr.A8319
Abstrakt:	Background and Purpose: Understanding sex-based differences in patients with glioblastoma is necessary for accurate personalized treatment planning to improve patient outcomes. Our purpose was to investigate sex-specific differences in molecular, clinical, and radiologic tumor parameters, as well as survival outcomes in patients with glioblastoma, isocitrate dehydrogenase-1 wild-type ( IDH1 -WT), grade 4. Materials and Methods: Retrospective data of 1832 patients with glioblastoma, IDH1 -WT with comprehensive information on tumor parameters was acquired from the Radiomics Signatures for Precision Oncology in Glioblastoma consortium. Data imputation was performed for missing values. Sex-based differences in tumor parameters, such as age, molecular parameters, preoperative Karnofsky performance score (KPS), tumor volumes, epicenter, and laterality were assessed through nonparametric tests. Spatial atlases were generated by using preoperative MRI maps to visualize tumor characteristics. Survival time analysis was performed through log-rank tests and Cox proportional hazard analyses. Results: Glioblastoma was diagnosed at a median age of 64 years in women compared with 61.9 years in men (false discovery rate [FDR] = 0.003). Men had a higher KPS (above 80) as compared with women (60.4% women versus 69.7% men, FDR = 0.044). Women had lower tumor volumes in enhancing (16.7 cm 3 versus 20.6 cm 3 in men, FDR = 0.001), necrotic core (6.18 cm 3 versus 7.76 cm 3 in men, FDR = 0.001), and edema regions (46.9 cm 3 versus 59.2 cm 3 in men, FDR = 0.0001). The right temporal region was the most common tumor epicenter in the overall population. Right as well as left temporal lobes were more frequently involved in men. There were no sex-specific differences in survival outcomes and mortality ratios. Higher age, unmethylated O6-methylguanine-DNA-methyltransferase promoter and undergoing subtotal resection increased the mortality risk in both men and women. Conclusions: Our study demonstrates significant sex-based differences in clinical and radiologic tumor parameters of patients with glioblastoma. Sex is not an independent prognostic factor for survival outcomes and the tumor parameters influencing patient outcomes are identical for men and women. (© 2024 by American Journal of Neuroradiology.)
Databáze:	MEDLINE
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