From flesh to bones: Multi-omics approaches in forensic science.

Autor: Procopio N; Research Centre for Field Archaeology and Experimental Taphonomy, School of Law and Policing, University of Central Lancashire, Preston, UK., Bonicelli A; Research Centre for Field Archaeology and Experimental Taphonomy, School of Law and Policing, University of Central Lancashire, Preston, UK.
Jazyk: angličtina
Zdroj: Proteomics [Proteomics] 2024 Jun; Vol. 24 (12-13), pp. e2200335. Date of Electronic Publication: 2024 Apr 29.
DOI: 10.1002/pmic.202200335
Abstrakt: Recent advancements in omics techniques have revolutionised the study of biological systems, enabling the generation of high-throughput biomolecular data. These innovations have found diverse applications, ranging from personalised medicine to forensic sciences. While the investigation of multiple aspects of cells, tissues or entire organisms through the integration of various omics approaches (such as genomics, epigenomics, metagenomics, transcriptomics, proteomics and metabolomics) has already been established in fields like biomedicine and cancer biology, its full potential in forensic sciences remains only partially explored. In this review, we have presented a comprehensive overview of state-of-the-art analytical platforms employed in omics research, with specific emphasis on their application in the forensic field for the identification of the cadaver and the cause of death. Moreover, we have conducted a critical analysis of the computational integration of omics approaches, and highlighted the latest advancements in employing multi-omics techniques for forensic investigations.
(© 2024 The Authors. PROTEOMICS published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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