Influence of a change in activity regime on femoral bone architecture and failure behaviour.

Autor: Villette CC; Department of Civil and Environmental Engineering, Structural Biomechanics, Imperial College London, London, United Kingdom.; The Royal British Legion Centre for Blast Injury Studies, Imperial College London, London, United Kingdom., Phillips ATM; Department of Civil and Environmental Engineering, Structural Biomechanics, Imperial College London, London, United Kingdom.; The Royal British Legion Centre for Blast Injury Studies, Imperial College London, London, United Kingdom.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Apr 29; Vol. 19 (4), pp. e0297932. Date of Electronic Publication: 2024 Apr 29 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0297932
Abstrakt: The incidence and morbidity of femoral fractures increases drastically with age. Femoral architecture and associated fracture risk are strongly influenced by loading during physical activities and it has been shown that the rate of loss of bone mineral density is significantly lower for active individuals than inactive. The objective of this work is to evaluate the impact of a cessation of some physical activities on elderly femoral structure and fracture behaviour. The authors previously established a biofidelic finite element model of the femur considered as a structure optimised to loading associated with daily activities. The same structural optimisation algorithm was used here to quantify the changes in bone architecture following cessation of stair climbing and sit-to-stand. Side fall fracture simulations were run on the adapted bone structures using a damage elasticity formulation. Total cortical and trabecular bone volume and failure load reduced in all cases of activity cessation. Bone loss distribution was strongly heterogeneous, with some locations even showing increased bone volume. This work suggests that maintaining the physical activities involved in the daily routine of a young healthy adult would help reduce the risk of femoral fracture in the elderly population by preventing bone loss.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Villette, Phillips. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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