Cell cycle variants during Drosophila male accessory gland development.

Autor: Box AM; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 1105 N. University Ave. Ann Arbor, MI 48109, USA., Ramesh NA; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 1105 N. University Ave. Ann Arbor, MI 48109, USA., Nandakumar S; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 1105 N. University Ave. Ann Arbor, MI 48109, USA., Church SJ; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 1105 N. University Ave. Ann Arbor, MI 48109, USA., Prasad D; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 1105 N. University Ave. Ann Arbor, MI 48109, USA., Afrakhteh A; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 1105 N. University Ave. Ann Arbor, MI 48109, USA., Taichman RS; Department of Periodontology, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Buttitta L; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 1105 N. University Ave. Ann Arbor, MI 48109, USA.
Jazyk: angličtina
Zdroj: G3 (Bethesda, Md.) [G3 (Bethesda)] 2024 Jul 08; Vol. 14 (7).
DOI: 10.1093/g3journal/jkae089
Abstrakt: The Drosophila melanogaster male accessory gland (AG) is a functional analog of the mammalian prostate and seminal vesicles containing two secretory epithelial cell types, termed main and secondary cells. This tissue is responsible for making and secreting seminal fluid proteins and other molecules that contribute to successful reproduction. The cells of this tissue are binucleate and polyploid, due to variant cell cycles that include endomitosis and endocycling during metamorphosis. Here, we provide evidence of additional cell cycle variants in this tissue. We show that main cells of the gland are connected by ring canals that form after the penultimate mitosis, and we describe an additional post-eclosion endocycle required for gland maturation that is dependent on juvenile hormone signaling. We present evidence that the main cells of the D. melanogaster AG undergo a unique cell cycle reprogramming throughout organ development that results in step-wise cell cycle truncations culminating in cells containing two octoploid nuclei with under-replicated heterochromatin in the mature gland. We propose this tissue as a model to study developmental and hormonal temporal control of cell cycle variants in terminally differentiating tissues.
Competing Interests: Conflicts of interest The author(s) declare no conflicts of interest.
(© The Author(s) 2024. Published by Oxford University Press on behalf of The Genetics Society of America.)
Databáze: MEDLINE
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