Current treatment strategies for targeting virulence factors and biofilm formation in Acinetobacter baumannii .
| Autor: | Rajangam SL; Department of Genetic Engineering, School of Bioengineering, College of Engineering & Technology, SRM Institute of Science & Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India., Narasimhan MK; Department of Genetic Engineering, School of Bioengineering, College of Engineering & Technology, SRM Institute of Science & Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India. |
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| Jazyk: | angličtina |
| Zdroj: | Future microbiology [Future Microbiol] 2024 Jul 02; Vol. 19 (10), pp. 941-961. Date of Electronic Publication: 2024 Apr 29. |
| DOI: | 10.2217/fmb-2023-0263 |
| Abstrakt: | A higher prevalence of Acinetobacter baumannii infections and mortality rate has been reported recently in hospital-acquired infections (HAI). The biofilm-forming capability of A. baumannii makes it an extremely dangerous pathogen, especially in device-associated hospital-acquired infections (DA-HAI), thereby it resists the penetration of antibiotics. Further, the transmission of the SARS-CoV-2 virus was exacerbated in DA-HAI during the epidemic. This review specifically examines the complex interconnections between several components and genes that play a role in the biofilm formation and the development of infections. The current review provides insights into innovative treatments and therapeutic approaches to combat A. baumannii biofilm-related infections, thereby ultimately improving patient outcomes and reducing the burden of HAI. |
| Databáze: | MEDLINE |
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