Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score.

Autor: Rosina S; IRCCS Istituto Giannina Gaslini, Genoa, Italy., Rebollo-Giménez AI; IRCCS Istituto Giannina Gaslini, Genoa, Italy., Tarantola L; Università degli Studi di Genova, Genoa, Italy., Pistorio A; IRCCS Istituto Giannina Gaslini, Genoa, Italy., Vyzhga Y; IRCCS Istituto Giannina Gaslini, Genoa, Italy., El Miedany Y; Canterbury Christ Church University, United Kingdom, and Egyptian College of Pediatric Rheumatology, Canterbury, Egypt., Lotfy HM; Abu El Reesh Hospital, Cairo University, Cairo, Egypt., Abu-Shady H; Abu El Reesh Hospital, Cairo University, Cairo, Egypt., Eissa M; Kasr Elainy Cairo University, Cairo, Egypt., Osman NS; Assiut University, Assiut, Egypt., Hassan W; Benha University, Benha, Egypt., Mahgoub MY; Benha University, Benha, Egypt., Fouad NA; Fayoum University, Fayoum, Egypt., Mosa DM; Mansoura University, Mansoura, Egypt., Adel Y; Mansoura University, Mansoura, Egypt., Mohamed SEM; Minia University Hospital, Minia, Egypt., Radwan AR; Sohag University, Sohag, Egypt., Abu-Zaid MH; Tanta University, Tanta, Egypt., Tabra SAA; Tanta University, Tanta, Egypt., Shalaby RH; Tanta University, Tanta, Egypt., Nasef SI; Suez Canal University, Ismailia, Egypt., Khubchandani R; NH SRCC Children Hospital, Mumbai, India., Khan A; NH SRCC Children Hospital, Mumbai, India., Maldar NP; NH SRCC Children Hospital, Mumbai, India., Ozen S; Hacettepe University, Ankara, Turkey., Bayindir Y; Hacettepe University, Ankara, Turkey., Alsuweiti M; Queen Rania Children's Hospital, King Hussein Medical Center, Royal Medical Services, Amman, Jordan., Alzyoud R; Queen Rania Children's Hospital, King Hussein Medical Center, Royal Medical Services, Amman, Jordan., Almaaitah H; Queen Rania Children's Hospital, King Hussein Medical Center, Royal Medical Services, Amman, Jordan., Vilaiyuk S; Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Lerkvaleekul B; Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Alexeeva E; National Medical Research Center of Children's Health and I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation., Dvoryakovskaya T; National Medical Research Center of Children's Health and I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation., Kriulin I; National Medical Research Center of Children's Health, Moscow, Russian Federation., Bracaglia C; IRCCS Bambino Gesù Children's Hospital, Rome, Italy., Pardeo M; IRCCS Bambino Gesù Children's Hospital, Rome, Italy., De Benedetti F; IRCCS Bambino Gesù Children's Hospital, Rome, Italy., Licciardi F; Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Torino, Italy., Montin D; Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Torino, Italy., Robasto F; Università degli studi di Torino, Torino, Italy., Minoia F; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Filocamo G; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Rossano M; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Simonini G; IRCCS Meyer Children's Hospital and University of Florence, Florence, Italy., Marrani E; IRCCS Meyer Children's Hospital, Florence, Italy., Abu-Rumeileh S; IRCCS Meyer Children's Hospital, Florence, Italy., Kostik MM; Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation., Belozerov KE; Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation., Pal P; Pediatric Rheumatology Institute of Child Health, Kolkata, India., Bathia JN; Pediatric Rheumatology Institute of Child Health, Kolkata, India., Katsicas MM; Hospital de Pediatría Prof Dr JP Garrahan, Buenos Aires, Argentina., Villarreal G; Hospital de Pediatría Prof Dr JP Garrahan, Buenos Aires, Argentina., Marino A; ASST G.Pini-CTO, Milan, Italy., Costi S; ASST G.Pini-CTO, Milan, Italy., Sztajnbok F; Universidade Federal do Rio de Janeiro and Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Silva RM; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Maggio MC; University of Palermo, Palermo, Italy., El-Ghoneimy DH; Children's Hospital, Ain Shams University, Cairo, Egypt., El Owaidy R; Children's Hospital, Ain Shams University, Cairo, Egypt., Civino A; 'Vito Fazzi' Hospital, Lecce, Italy., Diomeda F; 'Vito Fazzi' Hospital, Lecce, Italy., Al-Mayouf SM; King Faisal Specialist Hospital and Research Center, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Al-Sofyani F; King Faisal Specialist Hospital and Research Center, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Dāvidsone Z; University Children Hospital, Riga, Latvia., Patrone E; IRCCS Istituto Giannina Gaslini, Genoa, Italy., Saad-Magalhães C; São Paulo State University (UNESP), Botucatu, Brazil., Consolaro A; IRCCS Istituto Giannina Gaslini and Università degli Studi di Genova, Genoa, Italy., Ravelli A; IRCCS Istituto Giannina Gaslini and Università degli Studi di Genova, Genoa, Italy.
Jazyk: angličtina
Zdroj: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2024 Sep; Vol. 76 (9), pp. 1446-1454. Date of Electronic Publication: 2024 Jun 11.
DOI: 10.1002/art.42865
Abstrakt: Objective: Our objective was to develop and validate cutoff values in the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10) that distinguish the states of inactive disease (ID), minimal disease activity (MDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with systemic juvenile idiopathic arthritis, based on subjective disease state assessment by the treating pediatric rheumatologist.
Methods: The cutoff definition cohort was composed of 400 patients enrolled at 30 pediatric rheumatology centers in 11 countries. Using the subjective physician rating as an external criterion, six methods were applied to identify the cutoffs: mapping, calculation of percentiles of cumulative score distribution, the Youden index, 90% specificity, maximum agreement, and receiver operating characteristic curve analysis. Sixty percent of the patients were assigned to the definition cohort, and 40% were assigned to the validation cohort. Cutoff validation was conducted by assessing discriminative ability.
Results: The sJADAS10 cutoffs that separated ID from MDA, MDA from MoDA, and MoDA from HDA were ≤2.9, ≤10, and >20.6, respectively. The cutoffs discriminated strongly among different levels of pain, between patients with and without morning stiffness, and among patients whose parents judged their disease status as remission or persistent activity or flare or were satisfied or not satisfied with current illness outcome.
Conclusion: The sJADAS cutoffs revealed good metrologic properties in both definition and validation cohorts and are therefore suitable for use in clinical trials and routine practice.
(© 2024 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.)
Databáze: MEDLINE
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