Clearing the Fog: A Review of Antipsychotics for Parkinson's-Related Hallucinations: A Focus on Pimavanserin, Quetiapine and Clozapine.

Autor:	Abdul-Rahman T; Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Herrera-Calderón RE; Center for Research in Health Sciences (CICSA), Faculty of Medicine, Anahuac University North Campus, 52786 Huixquilucan, Mexico., Aderinto N; Department of Medicine and Surgery, Ladoke Akintola University of Technology, 210101 Ogbomoso, Nigeria., Kundu M; Department of General Medicine, Institute of Medical Sciences and SUM Hospital, 751003 Bhubaneswar, India., Wireko AA; Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Adebusoye FT; Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Ekerin O; School of Public Health, University of Port Harcourt, 500004 Port Harcourt, Nigeria., Lawal L; Faculty of Clinical Sciences, University of Ilorin, 240003 Ilorin, Nigeria., Mykolaivna NI; Medical Institute, Sumy State University, 40007 Sumy, Ukraine., Alexiou A; Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, NSW 2770, Australia.; Research & Development Department, AFNP Med, 1030 Wien, Austria., Almashjary MN; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.; Hematology Research Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.; Animal House Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589 Jeddah, Saudi Arabia., Perveen A; Glocal School of Life Sciences, Glocal University, 247121 Saharanpur, Uttar Pradesh, India.; Princess Dr. Najla Bint Saud Al-Saud Center for Excellence Research in Biotechnology, King Abdulaziz University, 21589 Jeddah, Saudi Arabia., Ashraf GM; Department of Medical Laboratory Sciences, College of Health Sciences, and Research Institute for Medical and Health Sciences, University of Sharjah, 27272 Sharjah, United Arab Emirates.
Jazyk:	angličtina
Zdroj:	Journal of integrative neuroscience [J Integr Neurosci] 2024 Apr 12; Vol. 23 (4), pp. 80.
DOI:	10.31083/j.jin2304080
Abstrakt:	Parkinson's disease is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms, including hallucinations. The use of antipsychotic medications is a common strategy to manage hallucinations associated with Parkinson's disease psychosis (PDP). However, careful consideration is necessary when selecting the most appropriate drug due to the potential risks associated with the available treatment options. Atypical antipsychotics (AAPs), such as Pimavanserin and Clozapine, have effectively controlled PDP symptoms. On the contrary, the support for utilizing quetiapine is not as substantial as other antipsychotics because research studies specifically investigating its application are still emerging and relatively recent. The broad mechanisms of action of AAPs, involving dopamine and serotonin receptors, provide improved outcomes and fewer side effects than typical antipsychotics. Conversely, other antipsychotics, including risperidone, olanzapine, aripiprazole, ziprasidone, and lurasidone, have been found to worsen motor symptoms and are generally not recommended for PDP. While AAPs offer favorable benefits, they are associated with specific adverse effects. Extrapyramidal symptoms, somnolence, hypotension, constipation, and cognitive impairment are commonly observed with AAP use. Clozapine, in particular, carries a risk of agranulocytosis, necessitating close monitoring of blood counts. Pimavanserin, a selective serotonin inverse agonist, avoids receptor-related side effects but has been linked to corrected QT (QTc) interval prolongation, while quetiapine has been reported to be associated with an increased risk of mortality. This review aims to analyze the benefits, risks, and mechanisms of action of antipsychotic medications to assist clinicians in making informed decisions and enhance patient care. Competing Interests: The authors declare no conflict of interest. Athanasios Alexiou and Ghulam Md Ashraf are serving as the Guest editors of this journal. We declare that Athanasios Alexiou and Ghulam Md Ashraf had no involvement in the peer review of this article and has no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to Gernot Riedel. Additionally Athanasios Alexiou is employed by AFNP Med Austria but he declares no conflict of interest with this work. (© 2024 The Author(s). Published by IMR Press.)
Databáze:	MEDLINE
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