Genetic Mapping and Phenotypic Analysis of GstE14 E.4.1 on Eye and Antennae Development in Drosophila melanogaster .

Autor:	Thomson L; Northern Illinois University, DeKalb, Illinois, United States., Shah HP; Northern Illinois University, DeKalb, Illinois, United States., Akinwotu Adewale V; University of St. Francis, Joliet, Illinois, United States., Beise A; Anoka-Ramsey Community College, Coon Rapids, Minnesota, United States., Bliayang C; Anoka-Ramsey Community College, Coon Rapids, Minnesota, United States., Cioch Z; Northern Illinois University, DeKalb, Illinois, United States., Craig M; University of St. Francis, Joliet, Illinois, United States., Crump A; Northern Illinois University, DeKalb, Illinois, United States., Durdan M; Northern Illinois University, DeKalb, Illinois, United States., Espinosa M; Northern Illinois University, DeKalb, Illinois, United States., Feda K; Northern Illinois University, DeKalb, Illinois, United States., Feist J; Anoka-Ramsey Community College, Coon Rapids, Minnesota, United States., Fragoso A; University of St. Francis, Joliet, Illinois, United States., Haro G; University of St. Francis, Joliet, Illinois, United States., Hoffman B; Anoka-Ramsey Community College, Coon Rapids, Minnesota, United States., Horne P; Northern Illinois University, DeKalb, Illinois, United States., Houha N; Northern Illinois University, DeKalb, Illinois, United States., Hounnou S; Northern Illinois University, DeKalb, Illinois, United States., Inman A; Anoka-Ramsey Community College, Coon Rapids, Minnesota, United States., Jakobsze D; Northern Illinois University, DeKalb, Illinois, United States., Juarez-Morales Y; Northern Illinois University, DeKalb, Illinois, United States., Khan Y; Northern Illinois University, DeKalb, Illinois, United States., Kohler J; Northern Illinois University, DeKalb, Illinois, United States., Lawlor R; Anoka-Ramsey Community College, Coon Rapids, Minnesota, United States., Lieser B; Anoka-Ramsey Community College, Coon Rapids, Minnesota, United States., Loitz R; Northern Illinois University, DeKalb, Illinois, United States., Martinez E; Northern Illinois University, DeKalb, Illinois, United States., Martinez A; Northern Illinois University, DeKalb, Illinois, United States., Martinez M; Anoka-Ramsey Community College, Coon Rapids, Minnesota, United States., Maza B; Northern Illinois University, DeKalb, Illinois, United States., Mendoza B; Northern Illinois University, DeKalb, Illinois, United States., Miller S; Northern Illinois University, DeKalb, Illinois, United States., Mngodo H; Northern Illinois University, DeKalb, Illinois, United States., O'Shea S; Northern Illinois University, DeKalb, Illinois, United States., Piane SN; University of St. Francis, Joliet, Illinois, United States., Raivala E; Anoka-Ramsey Community College, Coon Rapids, Minnesota, United States., Ruger S; Northern Illinois University, DeKalb, Illinois, United States., Singer A; Northern Illinois University, DeKalb, Illinois, United States., Strand JE; Anoka-Ramsey Community College, Coon Rapids, Minnesota, United States., Traylor A; Northern Illinois University, DeKalb, Illinois, United States., Wright A; Northern Illinois University, DeKalb, Illinois, United States., McCabe S; Anoka-Ramsey Community College, Coon Rapids, Minnesota, United States., Pandit SS; Northern Illinois University, DeKalb, Illinois, United States., Bieser K; Nevada State University, Henderson, Nevada, United States., Croonquist P; Anoka-Ramsey Community College, Coon Rapids, Minnesota, United States., Taylor EE; Northern Illinois University, DeKalb, Illinois, United States., Wittke-Thompson J; University of St. Francis, Joliet, Illinois, United States., Kagey JD; Universty of Detroit Mercy, Detroit, Michigan, United States., Devergne O; Northern Illinois University, DeKalb, Illinois, United States.
Jazyk:	angličtina
Zdroj:	MicroPublication biology [MicroPubl Biol] 2024 Apr 13; Vol. 2024. Date of Electronic Publication: 2024 Apr 13 (Print Publication: 2024).
DOI:	10.17912/micropub.biology.001019
Abstrakt:	Genetic screens are valuable for identifying novel genes involved in the regulation of developmental processes. To identify genes associated with cell growth regulation in Drosophila melanogaster , a mutagenesis screen was performed. Undergraduate students participating in Fly-CURE phenotypically characterized the E.4.1 mutant which is associated with rough eyes and antennae overgrowth. Following complementation analysis and subsequent genomic sequencing, E.4.1 was identified as a novel mutant allele of GstE14 , a gene involved in ecdysone biosynthesis important for the timing of developmental events. The abnormal eye and antenna phenotypes observed resulting from the loss of GstE14 suggest its role in tissue growth. Competing Interests: The authors declare that there are no conflicts of interest present. (Copyright: © 2024 by the authors.)
Databáze:	MEDLINE
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