Intrinsic and Extrinsic Contributors to the Cardiac Benefits of Exercise.

Autor:	Hastings MH; Institute for Heart and Brain Health, University of Michigan Medical Center, Ann Arbor, Michigan, USA., Castro C; Cardiovascular Research Center, Division of Cardiology, Corrigan Minehan Heart Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Freeman R; Cardiovascular Research Center, Division of Cardiology, Corrigan Minehan Heart Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Abdul Kadir A; Cardiovascular Research Center, Division of Cardiology, Corrigan Minehan Heart Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Lerchenmüller C; Department of Cardiology, University Hospital Heidelberg, German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany., Li H; Cardiovascular Research Center, Division of Cardiology, Corrigan Minehan Heart Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Rhee J; Cardiovascular Research Center, Division of Cardiology, Corrigan Minehan Heart Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Anesthesiology and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Roh JD; Cardiovascular Research Center, Division of Cardiology, Corrigan Minehan Heart Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Roh K; Cardiovascular Research Center, Division of Cardiology, Corrigan Minehan Heart Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Anesthesiology and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Singh AP; Institute for Heart and Brain Health, University of Michigan Medical Center, Ann Arbor, Michigan, USA., Wu C; Institute for Heart and Brain Health, University of Michigan Medical Center, Ann Arbor, Michigan, USA., Xia P; Cardiovascular Research Center, Division of Cardiology, Corrigan Minehan Heart Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Zhou Q; Institute for Heart and Brain Health, University of Michigan Medical Center, Ann Arbor, Michigan, USA., Xiao J; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China., Rosenzweig A; Institute for Heart and Brain Health, University of Michigan Medical Center, Ann Arbor, Michigan, USA.
Jazyk:	angličtina
Zdroj:	JACC. Basic to translational science [JACC Basic Transl Sci] 2023 Oct 18; Vol. 9 (4), pp. 535-552. Date of Electronic Publication: 2023 Oct 18 (Print Publication: 2024).
DOI:	10.1016/j.jacbts.2023.07.011
Abstrakt:	Among its many cardiovascular benefits, exercise training improves heart function and protects the heart against age-related decline, pathological stress, and injury. Here, we focus on cardiac benefits with an emphasis on more recent updates to our understanding. While the cardiomyocyte continues to play a central role as both a target and effector of exercise's benefits, there is a growing recognition of the important roles of other, noncardiomyocyte lineages and pathways, including some that lie outside the heart itself. We review what is known about mediators of exercise's benefits-both those intrinsic to the heart (at the level of cardiomyocytes, fibroblasts, or vascular cells) and those that are systemic (including metabolism, inflammation, the microbiome, and aging)-highlighting what is known about the molecular mechanisms responsible. Competing Interests: This work was supported by the National Institutes of Health (R01AG061034 and R35HL155318 [to Dr Rosenzweig], R21AG077040 [to Dr Li], K08HL140200 [to Dr Rhee], T32HL007208 [to Dr Xia], and K76AG064328 [to Dr Roh]), the American Heart Association (20CDA35310184 [to Dr Li]), the German Research Foundation (grant number LE3257/1-1 [to Dr Lerchenmüller]), the Olympia Morata Fellowship and project support by the University of Heidelberg Medical Faculty (to Dr Lerchenmüller), the Else-Kröner-Fresenius-Stiftung (2019-A07 [to Dr Lerchenmüller]), the National Natural Science Foundation of China (82020108002 [to Dr Xiao] and 82200321 [to Dr Zhou]), and the Shanghai Sailing Program (21YF1413200 [to Dr Zhou]). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. (© 2024 The Authors.)
Databáze:	MEDLINE
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