Diterpenes Isolated from Three Different Plectranthus Sensu Lato Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells.
| Autor: | Gáborová M; Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, 612 00 Brno, Czechia., Vágvölgyi M; Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary., Tayeb BA; Institute of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary., Minorics R; Institute of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary., Zupkó I; Institute of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary., Jurček O; Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, 612 00 Brno, Czechia.; Department of Chemistry, Faculty of Science, Masaryk University, 625 00 Brno, Czechia.; National Center for Biomolecular Research, Faculty of Science, Masaryk University, 625 00 Brno, Czechia., Béni S; Department of Analytical Chemistry, Institute of Chemistry, Eötvös Loránd University, 1117 Budapest, Hungary.; Department of Pharmacognosy, Semmelweis University, 1085 Budapest, Hungary., Kubínová R; Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, 612 00 Brno, Czechia., Balogh GT; Department of Pharmaceutical Chemistry, Semmelweis University, 1092 Budapest, Hungary., Hunyadi A; Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary.; HUN-REN-SZTE Biologically Active Natural Products Research Group, 6720 Szeged, Hungary.; Interdisciplinary Centre of Natural Products, University of Szeged, 6720 Szeged, Hungary. |
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| Jazyk: | angličtina |
| Zdroj: | ACS omega [ACS Omega] 2024 Apr 08; Vol. 9 (16), pp. 18495-18504. Date of Electronic Publication: 2024 Apr 08 (Print Publication: 2024). |
| DOI: | 10.1021/acsomega.4c00800 |
| Abstrakt: | Fourteen diterpenes were isolated from methanol extracts of the aerial parts of Coleus comosus , Coleus forsteri "Marginatus", and Plectranthus ciliatus . The compounds belong to the abietane ( 1 - 4 , 9 - 11 , and 13 ), ent -clerodane ( 5 - 8 ), and ent -kaurane ( 14 , 15 ) classes. Three new compounds were isolated from C. comosus , including 3- O -acetylornatin G ( 2 ), 3,12-di- O -acetylornatin G ( 3 ), ornatin B methyl ester ( 5 ), and ornatin F ( 4 ), for which we proposed a revised structure. The structures of the compounds were determined by comprehensive spectroscopic data analysis. The isolated diterpenes were examined in silico for their physicochemical and early ADME properties. Their antiproliferative effects were determined in vitro using human breast (MDA-MB-231 and MCF-7), cervical (HeLa), and glioblastoma (U-87 MG) cancer cell lines. The royleanone- and hydroquinone-type abietane diterpenes ( 9 - 13 )exhibited the most potent antiproliferative activity against all cancer cell lines tested, particularly against glioblastoma cells, with IC Competing Interests: The authors declare no competing financial interest. (© 2024 The Authors. Published by American Chemical Society.) |
| Databáze: | MEDLINE |
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