Sulfonamide Bioisosteres of Niclosamide Enhance Antibacterial Activity of Colistin and Bacitracin.

Autor: Berry L; Department of Chemistry, University of Manitoba, Winnipeg, MB, Canada., Ramirez D; Department of Chemistry, University of Manitoba, Winnipeg, MB, Canada., Domalaon R; Department of Chemistry, University of Manitoba, Winnipeg, MB, Canada., Schweizer F; Department of Chemistry, University of Manitoba, Winnipeg, MB, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Jazyk: angličtina
Zdroj: ChemMedChem [ChemMedChem] 2024 Aug 01; Vol. 19 (15), pp. e202400175. Date of Electronic Publication: 2024 Jun 15.
DOI: 10.1002/cmdc.202400175
Abstrakt: Multicomponent therapy combining antibiotics with enhancer molecules known as adjuvants is an emerging strategy to combat antimicrobial resistance. Niclosamide is a clinically relevant anthelmintic drug with potential to be repurposed for its inherent antibacterial activity against Gram-positive bacteria and its ability to potentiate the antibacterial activity of colistin against susceptible and resistant Gram-negative bacteria. Herein, sulfonamide analogs of niclosamide were prepared and found to enhance colistin activity against Gram-negative bacteria. The ability of niclosamide and the new sulfonamide analogs to synergize with bacitracin against vancomycin-resistant Enterococcus faecium was also discovered.
(© 2024 The Authors. ChemMedChem published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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