Harnessing probiotics capability to combat Salmonella Heidelberg and improve intestinal health in broilers.

Autor:	Hoepers PG; Veterinary Medicine College, Federal University of Uberlândia, Uberlândia, Brazil. Electronic address: patriciag.hoepers@gmail.com., Nunes PLF; Graduate Program in Genetics and Biochemistry, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil., Almeida-Souza HO; Graduate Program in Genetics and Biochemistry, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil., Martins MM; Graduate Program in Genetics and Biochemistry, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil., Carvalho RDO; School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil., Dreyer CT; Veterinary Medicine College, Federal University of Uberlândia, Uberlândia, Brazil., Aburjaile FF; School of Veterinary Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil., Sommerfeld S; Veterinary Medicine College, Federal University of Uberlândia, Uberlândia, Brazil., Azevedo V; School of Veterinary Medicine and Animal Science, Federal University of Bahia, Salvador, Brazil., Fonseca BB; Veterinary Medicine College, Federal University of Uberlândia, Uberlândia, Brazil; Graduate Program in Genetics and Biochemistry, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil.
Jazyk:	angličtina
Zdroj:	Poultry science [Poult Sci] 2024 Jul; Vol. 103 (7), pp. 103739. Date of Electronic Publication: 2024 Apr 05.
DOI:	10.1016/j.psj.2024.103739
Abstrakt:	The poultry industry faces significant challenges in controlling Salmonella contamination while reducing antibiotic use, particularly with the emergence of Salmonella Heidelberg (SH) strains posing risks to food safety and public health. Probiotics, notably lactic acid bacteria (LAB) and Saccharomyces boulardii (SB) offer promising alternatives for mitigating Salmonella colonization in broilers. Understanding the efficacy of probiotics in combating SH and their impact on gut health and metabolism is crucial for improving poultry production practices and ensuring food safety standards. This study aimed to assess the inhibitory effects of LAB and SB against SH both in vitro and in vivo broilers, while also investigating their impact on fecal metabolites and caecal microbiome composition. In vitro analysis demonstrated strong inhibition of SH by certain probiotic strains, such as Lactiplantibacillus plantarum (LP) and Lacticaseibacillus acidophilus (LA), while others like SB and Lactobacillus delbrueckii (LD) did not exhibit significant inhibition. In vivo testing revealed that broilers receiving probiotics had significantly lower SH concentrations in cecal content compared to the positive control (PC) at all ages, indicating a protective effect of probiotics against SH colonization. Metagenomic analysis of cecal-content microbiota identified predominant bacterial families and genera, highlighting changes in microbiota composition with age and probiotic supplementation. Additionally, fecal metabolomics profiling showed alterations in metabolite concentrations, suggesting reduced oxidative stress, intestinal inflammation, and improved gut health in probiotic-supplemented birds. These findings underscore the potential of probiotics to mitigate SH colonization and improve broiler health while reducing reliance on antibiotics. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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