Dynamic disability measures decrease the clinico-radiological gap in people with severely affected multiple sclerosis.

Autor: Jakimovski D; Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA., Weinstock-Guttman B; Department of Neurology, Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA., Burnham A; The Boston Home, Dorchester, MA, USA., Weinstock Z; Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA., Wicks TR; Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA., Ramanathan M; Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA., Sciortino T; Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA., Ostrem M; The Boston Home, Dorchester, MA, USA., Suchan C; Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA., Dwyer MG; Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA., Reilly J; The Boston Home, Dorchester, MA, USA; Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA., Bergsland N; Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA., Schweser F; Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA., Kennedy C; Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA., Young-Hong D; The Boston Home, Dorchester, MA, USA., Eckert SP; Department of Neurology, Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA., Hojnacki D; Department of Neurology, Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA., Benedict RH; Department of Neurology, Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA., Zivadinov R; Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA.
Jazyk: angličtina
Zdroj: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2024 Jul; Vol. 87, pp. 105630. Date of Electronic Publication: 2024 Apr 22.
DOI: 10.1016/j.msard.2024.105630
Abstrakt: Background: Expanded Disability Status Scale (EDSS) is limited when utilized in highly disabled people with multiple sclerosis (pwMS).
Objetive: To explore the relationship between disability measures and MRI outcomes in severely-affected pwMS.
Methods: PwMS recruited from The Boston Home (TBH), a specialized residential facility for severly-affected pwMS and University at Buffalo (UB) MS Center were assessed using EDSS, MS Severity Scale, age-related MSS, Scripps Neurological Rating Scale (SNRS) and Combinatorial Weight-Adjusted Disability Score (CombiWISE). In all scores except SNRS, higher score indicates greater disability. MRI measures of T1, T2-lesion volume (LV), whole brain, gray matter, medulla oblongata and thalamic volumes (WBV, GMV, MOV, TV) and thalamic dysconnectivity were obtained.
Results: Greatest disability differences between the TBH and UB pwMS were in SNRS (24.4 vs 71.9, p < 0.001, Cohen's d = 4.05) and CombiWISE (82.3 vs. 38.9, p < 0.001, Cohen's d = 4.02). In combined analysis of all pwMS, worse SNRS scores were correlated with worse MRI pathology in 8 out of 9 outcomes. EDSS only with 3 measures (GMV, MOV and TV). In severely-affected pwMS, SNRS was associated with T1-LV, T2-LV and WBV (not surviving false discovery rate (FDR) correction for multiple comparisons) whereas EDSS did not.
Conclusion: Granular and dynamic disability measures may bridge the clinico-radiologcal gap present in severely affected pwMS.
Competing Interests: Declaration of competing interest Dejan Jakimovski, Zachary Weinstock, Taylor Wicks, Christopher Suchan, Tommaso Sciortino, Niels Bergsland, Ferdinand Schweser, Cheryl Kennedy have nothing to disclose. Alex Burnham, Mark Ostrem, Jessica Reilly and David Young-Hong are employees of the Boston Home. Murali Ramanathan received research funding from the Department of Defense, National Science Foundation, and the National Institutes of Health. Michael G. Dwyer has received personal compensation from Mapi Pharma for consultant fees. He received financial support for research activities from Bristol Myers Squibb, Mapi Pharma, Protembis and V-WAVE Medical. Svetlana Eckert received consultant fees from Genentech. David Hojnacki received speaking and consulting from Biogen Idec and Bristol Myers Squibb. Ralph HB. Benedict has received consultation or speaking fees from Bristol Myer Squibb, Biogen, Merck, EMD Serono, Roche, Verasci, Immune Therapeutics, Novartis, and Sanofi-Genzyme. Bianca Weinstock-Guttman has received grant/research support Novartis, Genentech, EMD Serono, Celgene/Bristol Meyers Squibb, Sanofi &Genzyme, Janssen, Horizon, Bayer, Labcorp and has participated in speaker's bureaus for Biogen. She serves in the editorial board for BMJ Neurology, Children, CNS Drugs, MS International, Journal of Neurology and Frontiers Epidemiology. Robert Zivadinov has received personal compensation from Bristol Myers Squibb, EMD Serono, Sanofi, Janssen, Sanofi, 415 Capital, Filterlex and Mapi Pharma for speaking and consultant fees. He received financial support for research activities from Novartis, Bristol Myers Squibb, EMD Serono, Octave, Mapi Pharma, CorEvitas, Protembis and V-WAVE Medical.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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