Higher-order thalamocortical circuits are specified by embryonic cortical progenitor types in the mouse brain.

Autor:	Buchan MJ; Department of Pharmacology, Mansfield Road, OX1 3QT Oxford, UK., Gothard G; Department of Pharmacology, Mansfield Road, OX1 3QT Oxford, UK., Mahfooz K; Department of Pharmacology, Mansfield Road, OX1 3QT Oxford, UK., van Rheede JJ; Department of Pharmacology, Mansfield Road, OX1 3QT Oxford, UK., Avery SV; Department of Pharmacology, Mansfield Road, OX1 3QT Oxford, UK., Vourvoukelis A; Department of Pharmacology, Mansfield Road, OX1 3QT Oxford, UK., Demby A; Department of Pharmacology, Mansfield Road, OX1 3QT Oxford, UK., Ellender TJ; Department of Pharmacology, Mansfield Road, OX1 3QT Oxford, UK; Experimental Neurobiology Unit, Universiteitsplein, 2610 Antwerp, Belgium., Newey SE; Department of Pharmacology, Mansfield Road, OX1 3QT Oxford, UK., Akerman CJ; Department of Pharmacology, Mansfield Road, OX1 3QT Oxford, UK. Electronic address: colin.akerman@pharm.ox.ac.uk.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2024 May 28; Vol. 43 (5), pp. 114157. Date of Electronic Publication: 2024 Apr 26.
DOI:	10.1016/j.celrep.2024.114157
Abstrakt:	The sensory cortex receives synaptic inputs from both first-order and higher-order thalamic nuclei. First-order inputs relay simple stimulus properties from the periphery, whereas higher-order inputs relay more complex response properties, provide contextual feedback, and modulate plasticity. Here, we reveal that a cortical neuron's higher-order input is determined by the type of progenitor from which it is derived during embryonic development. Within layer 4 (L4) of the mouse primary somatosensory cortex, neurons derived from intermediate progenitors receive stronger higher-order thalamic input and exhibit greater higher-order sensory responses. These effects result from differences in dendritic morphology and levels of the transcription factor Lhx2, which are specified by the L4 neuron's progenitor type. When this mechanism is disrupted, cortical circuits exhibit altered higher-order responses and sensory-evoked plasticity. Therefore, by following distinct trajectories, progenitor types generate diversity in thalamocortical circuitry and may provide a general mechanism for differentially routing information through the cortex. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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