Association of Matrix Metalloproteinase-9 Genotypes With Lung Cancer Risk in Taiwan.

Autor:	Chen LH; Division of Chest Medicine, Department of Internal Medicine, Taichung Tzu Chi Hospital, Taichung, Taiwan, R.O.C.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C., Tsai YF; Department of Diagnostic Radiology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, R.O.C.; School of Medicine, Fu-Jen Catholic University, New Taipei, Taiwan, R.O.C., Wu WT; Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C., Chiu KL; Division of Chest Medicine, Department of Internal Medicine, Taichung Tzu Chi Hospital, Taichung, Taiwan, R.O.C., Tsai CW; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C., Chang WS; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C., Li CH; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C., Yang JS; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C., Mong MC; Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C., Hsia TC; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.; derrick.hsia@msa.hinet.net.; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C., Bau DT; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; artbau2@gmail.com.; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2024 May; Vol. 44 (5), pp. 1845-1852.
DOI:	10.21873/anticanres.16986
Abstrakt:	Background/aim: Matrix metalloproteinase-9 (MMP-9) expression is upregulated in various diseases, including lung cancer. However, the role of MMP-9 genotype in lung cancer susceptibility remains uncertain. This study aimed to clarify the contribution of MMP-9 promoter rs3918242 genotypes to the risk of lung cancer in Taiwan. Materials and Methods: The MMP-9 rs3918242 genotypes of 358 lung cancer patients and 716 healthy controls were determined using polymerase chain reaction-restriction fragment length polymorphism methodology. Results: Individuals carrying the variant CT or TT genotype of MMP-9 rs3918242 did not demonstrate an increased risk of lung cancer compared to wild-type CC carriers [odds ratio (OR)=1.11 and 1.85, 95% confidence interval (95%CI)=0.82-1.48 and 0.91-3.76; p=0.5541 and 0.1280, respectively]. Moreover, individuals carrying the T allele did not show a higher lung cancer risk compared to those with the C allele (OR=1.21, 95%CI=0.95-1.54, p=0.1444). However, a significant association was observed between the MMP-9 rs3918242 TT genotype and lung cancer risk among non-smokers (OR=5.48, 95%CI=1.31-22.89, p=0.0181). Conclusion: The presence of the TT genotype for MMP-9 rs3918242 may indicate an elevated risk of lung cancer among non-smokers. (Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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